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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Glob+Pediatr+Health
2017 ; 4
(ä): 2333794X17725983
Nephropedia Template TP
gab.com Text
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English Wikipedia
Clinical Improvement of Subacute and Chronic Otitis Media With Effusion Treated
With Hyaluronic Acid Plus Hypertonic Solution via Nasal Lavage: A Randomized
Controlled Trial
#MMPMID28894768
Cioffi L
; Gallo P
; D'Avino A
; Carlomagno F
; Aloi G
; D'Onofrio A
; Del Gaizo D
; Giuliano M
; De Franchis R
; Sandomenico ML
; Pecoraro A
Glob Pediatr Health
2017[]; 4
(ä): 2333794X17725983
PMID28894768
show ga
Background. This study, a randomized controlled trial, aims to demonstrate a
clinically significant improvement in subacute and chronic otitis media with
effusion through the administration of hyaluronic acid associated with hypertonic
solution compared with the administration of hypertonic solution alone. The
setting was an outpatient clinic of 20 primary care pediatrician offices
affiliated with the 3 Local Health Units (Azienda Sanitaria Locale) of Naples.
Materials and Methods. The study was conducted for 6 months, from October 2014 to
the end of March 2015. The study saw the participation of 20 pediatricians who
were experts in pneumatic otoscopy, each of whom enrolled 15 children. Each
investigator was randomized to carry out the treatment with 3% hypertonic
solution or high-molecular-weight hyaluronic acid + 3% hypertonic solution.
Results. A total of 275 children were enrolled, of whom 11(equal to 4% ) were
lost to follow-up. A total of 264 children completed the trial according to the
protocol, 120 in the hyaluronic acid + hypertonic solution group and 144 in the
hypertonic solution group. Hyaluronic acid associated with hypertonic solution
and hypertonic solution alone administered by nasal lavage have proven to be safe
and effective in the treatment of prolonged otitis media with effusion (initial
score of -0.5, final score of 0.9, P < 001, for the hypertonic + hyaluronic acid
group; initial score of -0.3, final score of 0.2, P < .001, for the hypertonic
solution group). Though starting from a less favorable initial clinical score
(-0.5 vs -0.3, P < .016), hyaluronic acid associated with hypertonic solution
resulted in a significant increase in clinical healing (0.9 vs 0.2, P < .001).
One interesting outcome was the significant reduction in the consumption of drugs
(cortisone and antibiotics) during the follow-up.