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2017 ; 8
(ä): 56
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The Effects of Aerobic Exercises and 25(OH) D Supplementation on GLP1 and DPP4
Level in Type II Diabetic Patients
#MMPMID28900535
Rahimi N
; Samavati Sharif MA
; Goharian AR
; Pour AH
Int J Prev Med
2017[]; 8
(ä): 56
PMID28900535
show ga
BACKGROUND: The purpose of this study was to investigate the effects of an 8-week
aerobic exercise and supplementation of 25(OH)D3 on GLP1 and DDP4 levels in men
with type II diabetes. METHODS: In this semiexperimental research, among
40-60-year-old men with type II diabetes who were referred to the diabetic center
of Isabn-E Maryam hospital in Isfahan; of whom, 48 patients were voluntarily
accepted and then were randomly divided into 4 groups: aerobic exercise group,
aerobic exercise with 25(OH) D supplement group, 25(OH) D supplement group, and
the control group. An aerobic exercise program was conducted for 8 weeks (3
sessions/week, each session 60 to75 min with 60-80% HRmax). The supplement user
group received 50,000 units of oral Vitamin D once weekly for 8 weeks. The GLP1,
DPP4, and 25(OH) D levels were measured before and after the intervention. At
last, the data were statistically analyzed using the ANCOVA and post hoc test of
least significant difference. RESULTS: The results of ANCOVA showed a significant
difference between the GLP1 and DPP4 levels in aerobic exercise with control
group while these changes were not statistically significant between the 25(OH) D
supplement group with control group (P < 0.05). CONCLUSIONS: Aerobic exercises
have resulted an increase in GLP1 level and a decrease in DPP4 level. However,
consumption of Vitamin D supplement alone did not cause any changes in GLP1and
DPP4 levels but led to an increase in 25-hydroxy Vitamin D level.
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