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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cardiovasc+Diagn+Ther
2017 ; 7
(4
): 348-358
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gab.com Text
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English Wikipedia
Type 2 versus type 1 myocardial infarction: a comparison of clinical
characteristics and outcomes with a meta-analysis of observational studies
#MMPMID28890871
Gupta S
; Vaidya SR
; Arora S
; Bahekar A
; Devarapally SR
Cardiovasc Diagn Ther
2017[Aug]; 7
(4
): 348-358
PMID28890871
show ga
BACKGROUND: Type 2 myocardial infarction (MI) is an imbalance between myocardial
oxygen demand and supply, leading to myocardial ischemia. It is not due to plaque
rupture, and is usually caused by a condition other than coronary artery disease
(CAD). However, limited data are available comparing the prevalence of
traditional coronary risk factors and mortality between type 1 and type 2 MI. We
hypothesize that type 2 MI carries a higher mortality than type 1. METHODS: We
searched the databases of PubMed, EMBASE, CENTRAL, and MEDLINE for studies
comparing type 1 MI with type 2 MI. The baseline variables were compared in each
cohort. Summary risk ratios and 95% confidence intervals were calculated using
the random effects model to compare mortality between the two groups. RESULTS:
The included studies yielded 25,872 patients of whom 2,683 (10%) had type 2 MI.
Compared to the type 1 cohort, the type 2 cohort had significantly higher
inpatient (15% vs. 4.7%, P<0.00001), 30-day (17.6% vs. 5.3%, P<0.00001) and 1-yr
mortality (27% vs. 13%, P<0.00001), as well as higher 30-day major adverse
cardiovascular events (20% vs. 9%, P<0.0001). Operative stress (20%) was the most
common trigger of type 2 MI, followed by sepsis (19%), arrhythmia (18.63%), heart
failure (15%), and anemia (12%). CONCLUSIONS: Type 2 MI is a common entity and is
more common in females, older age groups, and in patients with multiple
comorbidities: it also tends to result in higher mortality.