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10.1111/cas.13302 http://scihub22266oqcxt.onion/10.1111/cas.13302 C5581514!5581514 !28627761     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28627761 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Sci 2017 ; 108 (9 ): 1787-1792 Nephropedia Template TP {{tp|p=28627761 |t=2017. Biological effects of hydrogen peroxide administered intratumorally with or without irradiation in murine tumors |pdf=|usr=}}{{28627761 }} gab.com Text Biological effects of hydrogen peroxide administered intratumorally with or without irradiation in murine tumors JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28627761 #FOAvip Despite insufficient laboratory data, radiotherapy after intratumoral injection of hydrogen peroxide (H(2) O(2) ) is increasingly being used clinically for radioresistant tumors. Especially, this treatment might become an alternative definitive treatment for early and advanced breast cancer in patients who refuse any type of surgery. The purpose of this study was to investigate the biological effects and appropriate combination methods of irradiation and H(2) O(2) in vivo. SCCVII tumor cells transplanted into the legs of C3H/HeN mice were used. Chronological changes of intratumoral distribution of oxygen bubbles after injection of H(2) O(2) were investigated using computed tomography. The effects of H(2) O(2) alone and in combination with single or five-fraction irradiation were investigated using a growth delay assay. The optimal timing of H(2) O(2) injection was investigated. Immunostaining of tumors was performed using the hypoxia marker pimonidazole. Oxygen bubbles decreased gradually and almost disappeared after 24 h. Administration of H(2) O(2) produced 2-3 days' tumor growth delay. Tumor regrowth was slowed further when H(2) O(2) was injected before irradiation. The group irradiated immediately after H(2) O(2) injection showed the longest tumor growth delay. Dose-modifying factors were 1.7-2.0 when combined with single irradiation and 1.3-1.5 with fractionated irradiation. Pimonidazole staining was weaker in tumors injected with H(2) O(2) . H(2) O(2) injection alone had modest antitumor effects. Greater tumor growth delays were demonstrated by combining irradiation and H(2) O(2) injection. The results of the present study could serve as a basis for evaluating results of various clinical studies on this treatment. Twit Text FOAVip Biological effects of hydrogen peroxide administered intratumorally with or without irradiation in murine tumors ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28627761 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28627761 #FOAvip English Wikipedia <ref>{{Cite pmid|28627761 }}</ref> Biological effects of hydrogen peroxide administered intratumorally with or without irradiation in murine tumors #MMPMID28627761 Takaoka T ; Shibamoto Y ; Matsuo M ; Sugie C ; Murai T ; Ogawa Y ; Miyakawa A ; Manabe Y ; Kondo T ; Nakajima K ; Okazaki D ; Tsuchiya T Cancer Sci 2017[Sep]; 108 (9 ): 1787-1792 PMID28627761 show ga Despite insufficient laboratory data, radiotherapy after intratumoral injection of hydrogen peroxide (H(2) O(2) ) is increasingly being used clinically for radioresistant tumors. Especially, this treatment might become an alternative definitive treatment for early and advanced breast cancer in patients who refuse any type of surgery. The purpose of this study was to investigate the biological effects and appropriate combination methods of irradiation and H(2) O(2) in vivo. SCCVII tumor cells transplanted into the legs of C3H/HeN mice were used. Chronological changes of intratumoral distribution of oxygen bubbles after injection of H(2) O(2) were investigated using computed tomography. The effects of H(2) O(2) alone and in combination with single or five-fraction irradiation were investigated using a growth delay assay. The optimal timing of H(2) O(2) injection was investigated. Immunostaining of tumors was performed using the hypoxia marker pimonidazole. Oxygen bubbles decreased gradually and almost disappeared after 24 h. Administration of H(2) O(2) produced 2-3 days' tumor growth delay. Tumor regrowth was slowed further when H(2) O(2) was injected before irradiation. The group irradiated immediately after H(2) O(2) injection showed the longest tumor growth delay. Dose-modifying factors were 1.7-2.0 when combined with single irradiation and 1.3-1.5 with fractionated irradiation. Pimonidazole staining was weaker in tumors injected with H(2) O(2) . H(2) O(2) injection alone had modest antitumor effects. Greater tumor growth delays were demonstrated by combining irradiation and H(2) O(2) injection. The results of the present study could serve as a basis for evaluating results of various clinical studies on this treatment. |Animals [MESH] |Carcinoma, Squamous Cell/pathology/*therapy [MESH] |Drug Evaluation, Preclinical [MESH] |Female [MESH] |Hydrogen Peroxide/*administration & dosage [MESH] |Injections, Intralesional [MESH] |Mice, Inbred C3H [MESH] |Neoplasm Transplantation [MESH] |Radiation Tolerance [MESH] |Radiation-Sensitizing Agents/*administration & dosage [MESH]Biological effects of hydrogen peroxide administered intratumorally wi(epmc).pdf DeepDyve Pubget Overpricing