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10.18632/oncotarget.17893 http://scihub22266oqcxt.onion/10.18632/oncotarget.17893 C5581148!5581148!28881849     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (32): 53763-79 Nephropedia Template TP {{tp|p=28881849|t=2017. Advances in single-cell RNA sequencing and its applications in cancer research |pdf=|usr=}}{{28881849}} gab.com Text Advances in single-cell RNA sequencing and its applications in cancer research JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28881849 #FOAvip Unlike population-level approaches, single-cell RNA sequencing enables transcriptomic analysis of an individual cell. Through the combination of high-throughput sequencing and bioinformatic tools, single-cell RNA-seq can detect more than 10,000 transcripts in one cell to distinguish cell subsets and dynamic cellular changes. After several years? development, single-cell RNA-seq can now achieve massively parallel, full-length mRNA sequencing as well as in situ sequencing and even has potential for multi-omic detection. One appealing area of single-cell RNA-seq is cancer research, and it is regarded as a promising way to enhance prognosis and provide more precise target therapy by identifying druggable subclones. Indeed, progresses have been made regarding solid tumor analysis to reveal intratumoral heterogeneity, correlations between signaling pathways, stemness, drug resistance, and tumor architecture shaping the microenvironment. Furthermore, through investigation into circulating tumor cells, many genes have been shown to promote a propensity toward stemness and the epithelial-mesenchymal transition, to enhance anchoring and adhesion, and to be involved in mechanisms of anoikis resistance and drug resistance. This review focuses on advances and progresses of single-cell RNA-seq with regard to the following aspects:1. Methodologies of single-cell RNA-seq2. Single-cell isolation techniques3. Single-cell RNA-seq in solid tumor research4. Single-cell RNA-seq in circulating tumor cell research5. Perspectives Twit Text FOAVip Advances in single-cell RNA sequencing and its applications in cancer research ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28881849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28881849 #FOAvip English Wikipedia <ref>{{Cite pmid|28881849}}</ref> Advances in single-cell RNA sequencing and its applications in cancer research #MMPMID28881849 Zhu S; Qing T; Zheng Y; Jin L; Shi L Oncotarget 2017[Aug]; 8 (32): 53763-79 PMID28881849show ga Unlike population-level approaches, single-cell RNA sequencing enables transcriptomic analysis of an individual cell. Through the combination of high-throughput sequencing and bioinformatic tools, single-cell RNA-seq can detect more than 10,000 transcripts in one cell to distinguish cell subsets and dynamic cellular changes. After several years? development, single-cell RNA-seq can now achieve massively parallel, full-length mRNA sequencing as well as in situ sequencing and even has potential for multi-omic detection. One appealing area of single-cell RNA-seq is cancer research, and it is regarded as a promising way to enhance prognosis and provide more precise target therapy by identifying druggable subclones. Indeed, progresses have been made regarding solid tumor analysis to reveal intratumoral heterogeneity, correlations between signaling pathways, stemness, drug resistance, and tumor architecture shaping the microenvironment. Furthermore, through investigation into circulating tumor cells, many genes have been shown to promote a propensity toward stemness and the epithelial-mesenchymal transition, to enhance anchoring and adhesion, and to be involved in mechanisms of anoikis resistance and drug resistance. This review focuses on advances and progresses of single-cell RNA-seq with regard to the following aspects:1. Methodologies of single-cell RNA-seq2. Single-cell isolation techniques3. Single-cell RNA-seq in solid tumor research4. Single-cell RNA-seq in circulating tumor cell research5. Perspectives äAdvances in single-cell RNA sequencing and its applications in cancer (epmc).pdf DeepDyve Pubget Overpricing