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2017 ; 8
(32
): 52457-52464
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Prognostic role of podocalyxin-like protein expression in various cancers: A
systematic review and meta-analysis
#MMPMID28881743
Wang J
; Zhao Y
; Qi R
; Zhu X
; Huang C
; Cheng S
; Wang S
; Qi X
Oncotarget
2017[Aug]; 8
(32
): 52457-52464
PMID28881743
show ga
Several studies were conducted to explore the prognostic significance of
podocalyxin-like protein (PODXL) expression in various cancers, with
contradictory. This study aims to summarize the prognostic significance of PODXL
expression in cancers. PubMed, the Cochrane Library and Embase were completely
retrieved. The prospective or retrospective studies focusing on the prognostic
role of PODXL expression in cancers were eligible. The endpoints were overall
survival (OS), disease-specific survival (DSS) and disease-free survival (DFS).12
studies involving a total of 5,309 patients were identified. The results
indicated that high PODXL expression was significantly associated with worse OS
when compared to the low PODXL expression (HR=1.76, 95%CI=1.53-2.04, p<0.00001;
I(2)=41%, p=0.08). And similar results were detected in the subgroup analysis of
analysis model, ethnicity, sample size, tumor type and antibody type. And the
results also showed that high PODXL expression was obviously related to shorter
DSS (HR=2.47, 95%CI=1.53-3.99, p=0.0002; I(2)=66%, p=0.03) and DFS (HR=2.12,
95%CI=1.58-2.85, p<0.00001; I(2)=19%, p=0.29). In conclusion, it was revealed
that high PODXL expression is an unfavorable predictor of OS, DSS and DFS in
patients with cancers, and high PODXL expression is a promising prognostic
biomarker for cancers, especially for patients in European.