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2017 ; 10
(ä): 1179547617723643
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English Wikipedia
Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to
Eosinophil-Induced Endomyocardial Fibrosis
#MMPMID28890659
Alam A
; Thampi S
; Saba SG
; Jermyn R
Clin Med Insights Case Rep
2017[]; 10
(ä): 1179547617723643
PMID28890659
show ga
Loeffler endocarditis is a rare restrictive cardiomyopathy caused by abnormal
endomyocardial infiltration of eosinophils, with subsequent tissue damage from
degranulation, eventually leading to fibrosis. Although an uncommon entity, it is
still a disease with significant morbidity and mortality. Often identified only
at late stages, treatment options are limited once fibrosis occurs, usually
requiring heart failure medications or surgical intervention. We present a unique
case of a woman with remote history of hypereosinophilic syndrome, attributed to
treatment of rheumatoid arthritis with infliximab, who presented with symptoms of
heart failure refractory to medical management and was found to have Loeffler
endocarditis. The severe progression of the disease required surgical
intervention with endocardial stripping to treat the right-sided diastolic heart
failure.