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10.1101/gr.218891.116 http://scihub22266oqcxt.onion/10.1101/gr.218891.116 C5580718!5580718!28774965     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Res 2017 ; 27 (9): 1597-607 Nephropedia Template TP {{tp|p=28774965|t=2017. Assembly and analysis of 100 full MHC haplotypes from the Danish population |pdf=|usr=}}{{28774965}} gab.com Text Assembly and analysis of 100 full MHC haplotypes from the Danish population JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=28774965 #FOAvip Genes in the major histocompatibility complex (MHC, also known as HLA) play a critical role in the immune response and variation within the extended 4-Mb region shows association with major risks of many diseases. Yet, deciphering the underlying causes of these associations is difficult because the MHC is the most polymorphic region of the genome with a complex linkage disequilibrium structure. Here, we reconstruct full MHC haplotypes from de novo assembled trios without relying on a reference genome and perform evolutionary analyses. We report 100 full MHC haplotypes and call a large set of structural variants in the regions for future use in imputation with GWAS data. We also present the first complete analysis of the recombination landscape in the entire region and show how balancing selection at classical genes have linked effects on the frequency of variants throughout the region. Twit Text FOAVip Assembly and analysis of 100 full MHC haplotypes from the Danish population ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=28774965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28774965 #FOAvip English Wikipedia <ref>{{Cite pmid|28774965}}</ref> Assembly and analysis of 100 full MHC haplotypes from the Danish population #MMPMID28774965 Jensen JM; Villesen P; Friborg RM; Mailund T; Besenbacher S; Schierup MH; Maretty L; Jensen JM; Petersen B; Sibbesen JA; Liu S; Villesen P; Skov L; Belling K; Have CT; Izarzugaza JM; Grosjean M; Bork-Jensen J; Grove J; Als TD; Huang S; Chang Y; Xu R; Ye W; Rao J; Guo X; Sun J; Cao H; Ye C; Beusekom Jv; Espeseth T; Flindt E; Friborg RM; Halager AE; Le Hellard S; Hultman CM; Lescai F; Li S; Lund O; Løngren P; Mailund T; Matey-Hernandez ML; Mors O; Pedersen CN; Sicheritz-Pontén T; Sullivan P; Syed A; Westergaard D; Yadav R; Li N; Xu X; Hansen T; Krogh A; Bolund L; Sørensen TI; Pedersen O; Gupta R; Rasmussen S; Besenbacher S; Børglum AD; Wang J; Eiberg H; Kristiansen K; Brunak S; Schierup MH Genome Res 2017[Sep]; 27 (9): 1597-607 PMID28774965show ga Genes in the major histocompatibility complex (MHC, also known as HLA) play a critical role in the immune response and variation within the extended 4-Mb region shows association with major risks of many diseases. Yet, deciphering the underlying causes of these associations is difficult because the MHC is the most polymorphic region of the genome with a complex linkage disequilibrium structure. Here, we reconstruct full MHC haplotypes from de novo assembled trios without relying on a reference genome and perform evolutionary analyses. We report 100 full MHC haplotypes and call a large set of structural variants in the regions for future use in imputation with GWAS data. We also present the first complete analysis of the recombination landscape in the entire region and show how balancing selection at classical genes have linked effects on the frequency of variants throughout the region. äAssembly and analysis of 100 full MHC haplotypes from the Danish popul(epmc).pdf DeepDyve Pubget Overpricing