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10.2174/1871520615666141216145417 http://scihub22266oqcxt.onion/10.2174/1871520615666141216145417 C5580392!5580392 !25511514     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25511514 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Anticancer+Agents+Med+Chem 2015 ; 15 (5 ): 657-71 Nephropedia Template TP {{tp|p=25511514 |t=2015. Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics |pdf=|usr=}}{{25511514 }} gab.com Text Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics JO: Anticancer Agents Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=25511514 #FOAvip Adenosine Monophosphate-Activated Protein Kinase or AMPK is a highly-conserved master-regulator of numerous cellular processes, including: Maintaining cellular-energy homeostasis, modulation of cytoskeletaldynamics, directing cell growth-rates and influencing cell-death pathways. AMPK has recently emerged as a promising molecular target in cancer therapy. In fact, AMPK deficiencies have been shown to enhance cell growth and proliferation, which is consistent with enhancement of tumorigenesis by AMPK-loss. Conversely, activation of AMPK is associated with tumor growth suppression via inhibition of the Mammalian Target of Rapamycin Complex-1 (mTORC1) or the mTOR signal pathway. The scientific communities' recognition that AMPK-activating compounds possess an anti-neoplastic effect has contributed to a rush of discoveries and developments in AMPK-activating compounds as potential anticancer-drugs. One such example is the class of compounds known as Biguanides, which include Metformin and Phenformin. The current review will showcase natural compounds and their derivatives that activate the AMPK-complex and signaling pathway. In addition, the biology and history of AMPK-signaling and AMPK-activating compounds will be overviewed, their anticancer-roles and mechanisms-of-actions will be discussed, and potential strategies for the development of novel, selective AMPK-activators with enhanced efficacy and reduced toxicity will be proposed. Twit Text FOAVip Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics ????Anticancer Agents Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=25511514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25511514 #FOAvip English Wikipedia <ref>{{Cite pmid|25511514 }}</ref> Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics #MMPMID25511514 Arkwright RT ; Deshmukh R ; Adapa N ; Stevens R ; Zonder E ; Zhang Z ; Farshi P ; Ahmed RS ; El-Banna HA ; Chan TH ; Dou QP Anticancer Agents Med Chem 2015[]; 15 (5 ): 657-71 PMID25511514 show ga Adenosine Monophosphate-Activated Protein Kinase or AMPK is a highly-conserved master-regulator of numerous cellular processes, including: Maintaining cellular-energy homeostasis, modulation of cytoskeletaldynamics, directing cell growth-rates and influencing cell-death pathways. AMPK has recently emerged as a promising molecular target in cancer therapy. In fact, AMPK deficiencies have been shown to enhance cell growth and proliferation, which is consistent with enhancement of tumorigenesis by AMPK-loss. Conversely, activation of AMPK is associated with tumor growth suppression via inhibition of the Mammalian Target of Rapamycin Complex-1 (mTORC1) or the mTOR signal pathway. The scientific communities' recognition that AMPK-activating compounds possess an anti-neoplastic effect has contributed to a rush of discoveries and developments in AMPK-activating compounds as potential anticancer-drugs. One such example is the class of compounds known as Biguanides, which include Metformin and Phenformin. The current review will showcase natural compounds and their derivatives that activate the AMPK-complex and signaling pathway. In addition, the biology and history of AMPK-signaling and AMPK-activating compounds will be overviewed, their anticancer-roles and mechanisms-of-actions will be discussed, and potential strategies for the development of novel, selective AMPK-activators with enhanced efficacy and reduced toxicity will be proposed. |AMP-Activated Protein Kinases/*metabolism [MESH] |Animals [MESH] |Antineoplastic Agents/chemistry/*pharmacology [MESH] |Cell Proliferation/drug effects [MESH] |Enzyme Activators/chemistry/*pharmacology [MESH] |Humans [MESH]Lessons from Nature: Sources and Strategies for Developing AMPK Activa(epmc).pdf DeepDyve Pubget Overpricing