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10.1038/emm.2017.122 http://scihub22266oqcxt.onion/10.1038/emm.2017.122 C5579512!5579512 !28857085     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28857085 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Mol+Med 2017 ; 49 (8 ): e370 Nephropedia Template TP {{tp|p=28857085 |t=2017. Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice |pdf=|usr=}}{{28857085 }} gab.com Text Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28857085 #FOAvip Chronic high-salt diet-associated renal injury is a key risk factor for the development of hypertension. However, the mechanism by which salt triggers kidney damage is poorly understood. Our study investigated how high salt (HS) intake triggers early renal injury by considering the 'gut-kidney axis'. We fed mice 2% NaCl in drinking water continuously for 8 weeks to induce early renal injury. We found that the 'quantitative' and 'qualitative' levels of the intestinal microflora were significantly altered after chronic HS feeding, which indicated the occurrence of enteric dysbiosis. In addition, intestinal immunological gene expression was impaired in mice with HS intake. Gut permeability elevation and enteric bacterial translocation into the kidney were detected after chronic HS feeding. Gut bacteria depletion by non-absorbable antibiotic administration restored HS loading-induced gut leakiness, renal injury and systolic blood pressure elevation. The fecal microbiota from mice fed chronic HS could independently cause gut leakiness and renal injury. Our current work provides a novel insight into the mechanism of HS-induced renal injury by investigating the role of the intestine with enteric bacteria and gut permeability and clearly illustrates that chronic HS loading elicited renal injury and dysfunction that was dependent on the intestine. Twit Text FOAVip Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28857085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28857085 #FOAvip English Wikipedia <ref>{{Cite pmid|28857085 }}</ref> Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice #MMPMID28857085 Hu J ; Luo H ; Wang J ; Tang W ; Lu J ; Wu S ; Xiong Z ; Yang G ; Chen Z ; Lan T ; Zhou H ; Nie J ; Jiang Y ; Chen P Exp Mol Med 2017[Aug]; 49 (8 ): e370 PMID28857085 show ga Chronic high-salt diet-associated renal injury is a key risk factor for the development of hypertension. However, the mechanism by which salt triggers kidney damage is poorly understood. Our study investigated how high salt (HS) intake triggers early renal injury by considering the 'gut-kidney axis'. We fed mice 2% NaCl in drinking water continuously for 8 weeks to induce early renal injury. We found that the 'quantitative' and 'qualitative' levels of the intestinal microflora were significantly altered after chronic HS feeding, which indicated the occurrence of enteric dysbiosis. In addition, intestinal immunological gene expression was impaired in mice with HS intake. Gut permeability elevation and enteric bacterial translocation into the kidney were detected after chronic HS feeding. Gut bacteria depletion by non-absorbable antibiotic administration restored HS loading-induced gut leakiness, renal injury and systolic blood pressure elevation. The fecal microbiota from mice fed chronic HS could independently cause gut leakiness and renal injury. Our current work provides a novel insight into the mechanism of HS-induced renal injury by investigating the role of the intestine with enteric bacteria and gut permeability and clearly illustrates that chronic HS loading elicited renal injury and dysfunction that was dependent on the intestine. |Acute Kidney Injury/*metabolism [MESH] |Animals [MESH] |Bacteroidetes/isolation & purification [MESH] |Blood Pressure/drug effects [MESH] |Dysbiosis/etiology/*microbiology [MESH] |Feces/microbiology [MESH] |Firmicutes/isolation & purification [MESH] |Gastrointestinal Microbiome/drug effects/genetics [MESH] |Gastrointestinal Tract/*pathology [MESH] |Gene Expression Profiling [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Permeability/drug effects [MESH] |RNA/genetics [MESH] |Sodium Chloride, Dietary/*adverse effects [MESH]Enteric dysbiosis-linked gut barrier disruption triggers early renal i(epmc).pdf DeepDyve Pubget Overpricing