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2017 ; 49
(8
): e369
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English Wikipedia
Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF
receptor expression and signaling
#MMPMID28857084
Kim JC
; Jung YS
; Lee HY
; Park JS
; Bae YS
Exp Mol Med
2017[Aug]; 49
(8
): e369
PMID28857084
show ga
In this study, we report that an acute phase reactant, serum amyloid A (SAA),
strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA
markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased
cell surface GM-CSF receptor expression. SAA also decreased the expression of
PU.1 and C/EBP?, which play roles in the expression of GM-CSF receptor. This
inhibitory response by SAA is partly mediated by the well-known SAA receptors,
Toll-like receptor 2 and formyl peptide receptor 2. Taken together, we suggest a
novel insight into the inhibitory role of SAA in dendritic cell differentiation.