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10.1007/s00232-016-9908-z http://scihub22266oqcxt.onion/10.1007/s00232-016-9908-z C5579164!5579164!27465729     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Membr+Biol 2017 ; 250 (4): 337-51 Nephropedia Template TP {{tp|p=27465729|t=2017. The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations |pdf=|usr=}}{{27465729}} gab.com Text The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations JO: J Membr Biol http://www.kidney.de/pget.php?&tw=1&pmid=27465729 #FOAvip Integrins are heterodimeric (??) cell surface receptors that are potential therapeutic targets for a number of diseases. Despite the existence of structural data for all parts of integrins, the structure of the complete integrin receptor is still not available. We have used available structural data to construct a model of the complete integrin receptor in complex with talin F2?F3 domain. It has been shown that the interactions of integrins with their lipid environment are crucial for their function but details of the integrin/lipid interactions remain elusive. In this study an integrin/talin complex was inserted in biologically relevant bilayers that resemble the cell plasma membrane containing zwitterionic and charged phospholipids, cholesterol and sphingolipids to study the dynamics of the integrin receptor and its effect on bilayer structure and dynamics. The results of this study demonstrate the dynamic nature of the integrin receptor and suggest that the presence of the integrin receptor alters the lipid organization between the two leaflets of the bilayer. In particular, our results suggest elevated density of cholesterol and of phosphatidylserine lipids around the integrin/talin complex and a slowing down of lipids in an annulus of ~30 Å around the protein due to interactions between the lipids and the integrin/talin F2?F3 complex. This may in part regulate the interactions of integrins with other related proteins or integrin clustering thus facilitating signal transduction across cell membranes.Electronic supplementary material: The online version of this article (doi:10.1007/s00232-016-9908-z) contains supplementary material, which is available to authorized users. Twit Text FOAVip The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations ????J Membr Biol http://www.kidney.de/pget.php?&tw=1&pmid=27465729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27465729 #FOAvip English Wikipedia <ref>{{Cite pmid|27465729}}</ref> The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations #MMPMID27465729 Kalli AC; Rog T; Vattulainen I; Campbell ID; Sansom MSP J Membr Biol 2017[]; 250 (4): 337-51 PMID27465729show ga Integrins are heterodimeric (??) cell surface receptors that are potential therapeutic targets for a number of diseases. Despite the existence of structural data for all parts of integrins, the structure of the complete integrin receptor is still not available. We have used available structural data to construct a model of the complete integrin receptor in complex with talin F2?F3 domain. It has been shown that the interactions of integrins with their lipid environment are crucial for their function but details of the integrin/lipid interactions remain elusive. In this study an integrin/talin complex was inserted in biologically relevant bilayers that resemble the cell plasma membrane containing zwitterionic and charged phospholipids, cholesterol and sphingolipids to study the dynamics of the integrin receptor and its effect on bilayer structure and dynamics. The results of this study demonstrate the dynamic nature of the integrin receptor and suggest that the presence of the integrin receptor alters the lipid organization between the two leaflets of the bilayer. In particular, our results suggest elevated density of cholesterol and of phosphatidylserine lipids around the integrin/talin complex and a slowing down of lipids in an annulus of ~30 Å around the protein due to interactions between the lipids and the integrin/talin F2?F3 complex. This may in part regulate the interactions of integrins with other related proteins or integrin clustering thus facilitating signal transduction across cell membranes.Electronic supplementary material: The online version of this article (doi:10.1007/s00232-016-9908-z) contains supplementary material, which is available to authorized users. äThe Integrin Receptor in Biologically Relevant Bilayers: Insights from(epmc).pdf DeepDyve Pubget Overpricing