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10.1371/journal.pntd.0005861 http://scihub22266oqcxt.onion/10.1371/journal.pntd.0005861 C5578697!5578697!28827803     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Negl+Trop+Dis 2017 ; 11 (8): ä Nephropedia Template TP {{tp|p=28827803|t=2017. Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha |pdf=|usr=}}{{28827803}} gab.com Text Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha JO: PLoS Negl Trop Dis http://www.kidney.de/pget.php?&tw=1&pmid=28827803 #FOAvip Interleukin-4 receptor (IL-4R?) is critical for the initiation of type-2 immune responses and implicated in the pathogenesis of experimental schistosomiasis. IL-4R? mediated type-2 responses are critical for the control of pathology during acute schistosomiasis. However, type-2 responses tightly associate with fibrogranulomatous inflammation that drives host pathology during chronic schistosomiasis. To address such controversy on the role of IL-4R?, we generated a novel inducible IL-4R?-deficient mouse model that allows for temporal knockdown of il-4r? gene after oral administration of Tamoxifen. Interrupting IL-4R? mediated signaling during the acute phase impaired the development of protective type-2 immune responses, leading to rapid weight loss and premature death, confirming a protective role of IL-4R? during acute schistosomiasis. Conversely, IL-4R? removal at the chronic phase of schistosomiasis ameliorated the pathological fibro-granulomatous pathology and reversed liver scarification without affecting the host fitness. This amelioration of the morbidity was accompanied by a reduced Th2 response and increased frequencies of FoxP3+ Tregs and CD1dhiCD5+ Bregs. Collectively, these data demonstrate that IL-4R? mediated signaling has two opposing functions during experimental schistosomiasis depending on the stage of advancement of the disease and indicate that interrupting IL-4R? mediated signaling is a viable therapeutic strategy to ameliorate liver fibroproliferative pathology in diseases like chronic schistosomiasis. Twit Text FOAVip Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha ????PLoS Negl Trop Dis http://www.kidney.de/pget.php?&tw=1&pmid=28827803 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28827803 #FOAvip English Wikipedia <ref>{{Cite pmid|28827803}}</ref> Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha #MMPMID28827803 Nono JK; Ndlovu H; Aziz NA; Mpotje T; Hlaka L; Brombacher F PLoS Negl Trop Dis 2017[Aug]; 11 (8): ä PMID28827803show ga Interleukin-4 receptor (IL-4R?) is critical for the initiation of type-2 immune responses and implicated in the pathogenesis of experimental schistosomiasis. IL-4R? mediated type-2 responses are critical for the control of pathology during acute schistosomiasis. However, type-2 responses tightly associate with fibrogranulomatous inflammation that drives host pathology during chronic schistosomiasis. To address such controversy on the role of IL-4R?, we generated a novel inducible IL-4R?-deficient mouse model that allows for temporal knockdown of il-4r? gene after oral administration of Tamoxifen. Interrupting IL-4R? mediated signaling during the acute phase impaired the development of protective type-2 immune responses, leading to rapid weight loss and premature death, confirming a protective role of IL-4R? during acute schistosomiasis. Conversely, IL-4R? removal at the chronic phase of schistosomiasis ameliorated the pathological fibro-granulomatous pathology and reversed liver scarification without affecting the host fitness. This amelioration of the morbidity was accompanied by a reduced Th2 response and increased frequencies of FoxP3+ Tregs and CD1dhiCD5+ Bregs. Collectively, these data demonstrate that IL-4R? mediated signaling has two opposing functions during experimental schistosomiasis depending on the stage of advancement of the disease and indicate that interrupting IL-4R? mediated signaling is a viable therapeutic strategy to ameliorate liver fibroproliferative pathology in diseases like chronic schistosomiasis. äHost regulation of liver fibroproliferative pathology during experimen(epmc).pdf DeepDyve Pubget Overpricing