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10.1002/eji.201747034 http://scihub22266oqcxt.onion/10.1002/eji.201747034 C5578616!5578616 !28586108     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28586108 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Immunol 2017 ; 47 (7 ): 1136-1141 Nephropedia Template TP {{tp|p=28586108 |t=2017. Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice |pdf=|usr=}}{{28586108 }} gab.com Text Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28586108 #FOAvip The transcription factors Bcl6 and Blimp1 have opposing roles in the development of the follicular helper T (T(FH) ) cells: Bcl6 promotes and Blimp1 inhibits T(FH) -cell differentiation. Similarly, Bcl6 activates, while Blimp1 represses, expression of the T(FH) -cell marker PD-1. However, Bcl6 and Blimp1 repress each other's expression, complicating the interpretation of the regulatory network. Here we sought to clarify the extent to which Bcl6 and Blimp1 independently control T(FH) -cell differentiation by generating mice with T-cell specific deletion of both Bcl6 and Blimp1 (double conditional KO [dcKO] mice). Our data indicate that Blimp1 does not control T(FH) -cell differentiation independently of Bcl6. However, a population of T follicular regulatory (T(FR) ) cells developed independently of Bcl6 in dcKO mice. We have also analyzed regulation of IL-10 and PD-1, two genes controlled by both Bcl6 and Blimp1, and observed that Bcl6 regulates both genes independently of Blimp1. We found that Bcl6 positively regulates PD-1 expression by inhibiting the ability of T-bet/Tbx21 to repress Pdcd1 transcription. Our data provide a novel mechanism for positive control of gene expression by Bcl6, and illuminate how Bcl6 and Blimp1 control T(FH) -cell differentiation. Twit Text FOAVip Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28586108 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28586108 #FOAvip English Wikipedia <ref>{{Cite pmid|28586108 }}</ref> Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice #MMPMID28586108 Xie MM ; Koh BH ; Hollister K ; Wu H ; Sun J ; Kaplan MH ; Dent AL Eur J Immunol 2017[Jul]; 47 (7 ): 1136-1141 PMID28586108 show ga The transcription factors Bcl6 and Blimp1 have opposing roles in the development of the follicular helper T (T(FH) ) cells: Bcl6 promotes and Blimp1 inhibits T(FH) -cell differentiation. Similarly, Bcl6 activates, while Blimp1 represses, expression of the T(FH) -cell marker PD-1. However, Bcl6 and Blimp1 repress each other's expression, complicating the interpretation of the regulatory network. Here we sought to clarify the extent to which Bcl6 and Blimp1 independently control T(FH) -cell differentiation by generating mice with T-cell specific deletion of both Bcl6 and Blimp1 (double conditional KO [dcKO] mice). Our data indicate that Blimp1 does not control T(FH) -cell differentiation independently of Bcl6. However, a population of T follicular regulatory (T(FR) ) cells developed independently of Bcl6 in dcKO mice. We have also analyzed regulation of IL-10 and PD-1, two genes controlled by both Bcl6 and Blimp1, and observed that Bcl6 regulates both genes independently of Blimp1. We found that Bcl6 positively regulates PD-1 expression by inhibiting the ability of T-bet/Tbx21 to repress Pdcd1 transcription. Our data provide a novel mechanism for positive control of gene expression by Bcl6, and illuminate how Bcl6 and Blimp1 control T(FH) -cell differentiation. |*Cell Differentiation [MESH] |Animals [MESH] |Gene Expression [MESH] |Gene Expression Regulation [MESH] |Germinal Center/immunology [MESH] |Interleukin-10/genetics/immunology [MESH] |Lymphocyte Activation [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Positive Regulatory Domain I-Binding Factor 1 [MESH] |Programmed Cell Death 1 Receptor/*genetics/immunology [MESH] |Proto-Oncogene Proteins c-bcl-6/deficiency/genetics/*metabolism [MESH] |Signal Transduction [MESH] |T-Box Domain Proteins/genetics/immunology/metabolism [MESH] |T-Lymphocytes, Helper-Inducer/*immunology [MESH] |T-Lymphocytes, Regulatory/immunology/physiology [MESH] |T-bet Transcription Factor [MESH]Bcl6 promotes follicular helper T-cell differentiation and PD-1 expres(epmc).pdf DeepDyve Pubget Overpricing