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10.3390/ijms18081704 http://scihub22266oqcxt.onion/10.3390/ijms18081704 C5578094!5578094 !28777298     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28777298 &cmd=llinks): Failed to open stream: HTTP request failed! 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The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice |pdf=|usr=}}{{28777298 }} gab.com Text The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28777298 #FOAvip Recent clinical studies have revealed the treatment of diabetic patients with sodium glucose co-transporter2 (SGLT2) inhibitors to reduce the incidence of cardiovascular events. Using nicotinamide and streptozotocin (NA/STZ) -treated ApoE KO mice, we investigated the effects of short-term (seven days) treatment with the SGLT2 inhibitor luseogliflozin on mRNA levels related to atherosclerosis in the aorta, as well as examining the long-term (six months) effects on atherosclerosis development. Eight-week-old ApoE KO mice were treated with NA/STZ to induce diabetes mellitus, and then divided into two groups, either untreated, or treated with luseogliflozin. Seven days after the initiation of luseogliflozin administration, atherosclerosis-related mRNA levels in the aorta were compared among four groups; i.e., wild type C57/BL6J, native ApoE KO, and NA/STZ-treated ApoE KO mice, with or without luseogliflozin. Short-term luseogliflozin treatment normalized the expression of inflammation-related genes such as F4/80, TNF?, IL-1?, IL-6, ICAM-1, PECAM-1, MMP2 and MMP9 in the NA/STZ-treated ApoE KO mice, which showed marked elevations as compared with untreated ApoE KO mice. In contrast, lipid metabolism-related genes were generally unaffected by luseogliflozin treatment. Furthermore, after six-month treatment with luseogliflozin, in contrast to the severe and widely distributed atherosclerotic changes in the aortas of NA/STZ-treated ApoE KO mice, luseogliflozin treatment markedly attenuated the progression of atherosclerosis, without affecting serum lipid parameters such as high density lipoprotein, low density lipoprotein and triglyceride levels. Given that luseogliflozin normalized the aortic mRNA levels of inflammation-related, but not lipid-related, genes soon after the initiation of treatment, it is not unreasonable to speculate that the anti-atherosclerotic effect of this SGLT2 inhibitor emerges rapidly, possibly via the prevention of inflammation rather than of hyperlipidemia. Twit Text FOAVip The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28777298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28777298 #FOAvip English Wikipedia <ref>{{Cite pmid|28777298 }}</ref> The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice #MMPMID28777298 Nakatsu Y ; Kokubo H ; Bumdelger B ; Yoshizumi M ; Yamamotoya T ; Matsunaga Y ; Ueda K ; Inoue Y ; Inoue MK ; Fujishiro M ; Kushiyama A ; Ono H ; Sakoda H ; Asano T Int J Mol Sci 2017[Aug]; 18 (8 ): ä PMID28777298 show ga Recent clinical studies have revealed the treatment of diabetic patients with sodium glucose co-transporter2 (SGLT2) inhibitors to reduce the incidence of cardiovascular events. Using nicotinamide and streptozotocin (NA/STZ) -treated ApoE KO mice, we investigated the effects of short-term (seven days) treatment with the SGLT2 inhibitor luseogliflozin on mRNA levels related to atherosclerosis in the aorta, as well as examining the long-term (six months) effects on atherosclerosis development. Eight-week-old ApoE KO mice were treated with NA/STZ to induce diabetes mellitus, and then divided into two groups, either untreated, or treated with luseogliflozin. Seven days after the initiation of luseogliflozin administration, atherosclerosis-related mRNA levels in the aorta were compared among four groups; i.e., wild type C57/BL6J, native ApoE KO, and NA/STZ-treated ApoE KO mice, with or without luseogliflozin. Short-term luseogliflozin treatment normalized the expression of inflammation-related genes such as F4/80, TNF?, IL-1?, IL-6, ICAM-1, PECAM-1, MMP2 and MMP9 in the NA/STZ-treated ApoE KO mice, which showed marked elevations as compared with untreated ApoE KO mice. In contrast, lipid metabolism-related genes were generally unaffected by luseogliflozin treatment. Furthermore, after six-month treatment with luseogliflozin, in contrast to the severe and widely distributed atherosclerotic changes in the aortas of NA/STZ-treated ApoE KO mice, luseogliflozin treatment markedly attenuated the progression of atherosclerosis, without affecting serum lipid parameters such as high density lipoprotein, low density lipoprotein and triglyceride levels. Given that luseogliflozin normalized the aortic mRNA levels of inflammation-related, but not lipid-related, genes soon after the initiation of treatment, it is not unreasonable to speculate that the anti-atherosclerotic effect of this SGLT2 inhibitor emerges rapidly, possibly via the prevention of inflammation rather than of hyperlipidemia. |*Sodium-Glucose Transporter 2 Inhibitors [MESH] |Animals [MESH] |Aorta/*metabolism [MESH] |Apolipoproteins E/*metabolism [MESH] |Atherosclerosis/complications/*drug therapy/genetics [MESH] |Cell Adhesion Molecules/metabolism [MESH] |Cytokines/metabolism [MESH] |Diabetes Mellitus, Experimental/complications/drug therapy/*genetics [MESH] |Gene Expression Regulation/drug effects [MESH] |Hyperglycemia/complications/drug therapy [MESH] |Hyperlipidemias/complications/drug therapy [MESH] |Inflammation/complications/*genetics [MESH] |Lipid Metabolism/drug effects/*genetics [MESH] |Lipid Peroxidation/drug effects [MESH] |Macrophages/drug effects/metabolism [MESH] |Matrix Metalloproteinases/metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Niacinamide [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Sodium-Glucose Transporter 2/metabolism [MESH] |Sorbitol/*analogs & derivatives/pharmacology/therapeutic use [MESH] |Streptozocin [MESH]The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Leve(epmc).pdf DeepDyve Pubget Overpricing