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10.3390/ijms18081683 http://scihub22266oqcxt.onion/10.3390/ijms18081683 C5578073!5578073!28767098     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2017 ; 18 (8): ä Nephropedia Template TP {{tp|p=28767098|t=2017. Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes |pdf=|usr=}}{{28767098}} gab.com Text Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28767098 #FOAvip Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics. Twit Text FOAVip Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28767098 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28767098 #FOAvip English Wikipedia <ref>{{Cite pmid|28767098}}</ref> Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes #MMPMID28767098 Ni S; Yao H; Wang L; Lu J; Jiang F; Lu A; Zhang G Int J Mol Sci 2017[Aug]; 18 (8): ä PMID28767098show ga Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics. äChemical Modifications of Nucleic Acid Aptamers for Therapeutic Purpos(epmc).pdf DeepDyve Pubget Overpricing