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10.3390/ijms18081682

http://scihub22266oqcxt.onion/10.3390/ijms18081682
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C5578072!5578072!28767097
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suck abstract from ncbi


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pmid28767097      Int+J+Mol+Sci 2017 ; 18 (8): ä
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  • Sympathetic Overactivity in Chronic Kidney Disease: Consequences and Mechanisms #MMPMID28767097
  • Kaur J; Young BE; Fadel PJ
  • Int J Mol Sci 2017[Aug]; 18 (8): ä PMID28767097show ga
  • The incidence of chronic kidney disease (CKD) is increasing worldwide, with more than 26 million people suffering from CKD in the United States alone. More patients with CKD die of cardiovascular complications than progress to dialysis. Over 80% of CKD patients have hypertension, which is associated with increased risk of cardiovascular morbidity and mortality. Another common, perhaps underappreciated, feature of CKD is an overactive sympathetic nervous system. This elevation in sympathetic nerve activity (SNA) not only contributes to hypertension but also plays a detrimental role in the progression of CKD independent of any increase in blood pressure. Indeed, high SNA is associated with poor prognosis and increased cardiovascular morbidity and mortality independent of its effect on blood pressure. This brief review will discuss some of the consequences of sympathetic overactivity and highlight some of the potential pathways contributing to chronically elevated SNA in CKD. Mechanisms leading to chronic sympathoexcitation in CKD are complex, multifactorial and to date, not completely understood. Identification of the mechanisms and/or signals leading to sympathetic overactivity in CKD are crucial for development of effective therapeutic targets to reduce the increased cardiovascular risk in this patient group.
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