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10.3390/ijms18081662 http://scihub22266oqcxt.onion/10.3390/ijms18081662 C5578052!5578052 !28758975     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28758975 &cmd=llinks): Failed to open stream: HTTP request failed! 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Elevated Soluble Urokinase Plasminogen Activator Receptor and Proenkephalin Serum Levels Predict the Development of Acute Kidney Injury after Cardiac Surgery |pdf=|usr=}}{{28758975 }} gab.com Text Elevated Soluble Urokinase Plasminogen Activator Receptor and Proenkephalin Serum Levels Predict the Development of Acute Kidney Injury after Cardiac Surgery JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28758975 #FOAvip Acute kidney injury (AKI) develops in up to 40% of patients after cardiac surgery. The soluble urokinase plasminogen activator receptor (suPAR) has been identified as a biomarker for incident chronic kidney disease (CKD). Proenkephalin (proENK) also has been shown to be a biomarker for renal dysfunction. We hypothesized that pre-surgery suPAR and proENK levels might predict AKI in patients undergoing cardiac surgery. Consecutive patients (n = 107) undergoing elective cardiac surgery were studied prospectively. Clinical data, laboratory parameters, suPAR and proENK serum levels were assessed before operation, after operation and days one and four post-operatively. A total of 21 (19.6%) patients developed AKI within the first four days after elective surgery. Serum levels of suPAR and proENK, but not of creatinine, were significantly higher before surgery in these patients compared to those patients without AKI. This difference remained significant for suPAR, if patients with or without AKI were matched for risk factors (hypertension, diabetes, CKD). If cardiac surgery patients with pre-existing CKD (n = 10) were excluded, only pre-operative suPAR but not proENK serum levels remained significantly elevated in patients with subsequent AKI. Thus, our findings indicate that suPAR may be a predictive biomarker for AKI in the context of cardiac surgery, even in patients without underlying CKD. Twit Text FOAVip Elevated Soluble Urokinase Plasminogen Activator Receptor and Proenkephalin Serum Levels Predict the Development of Acute Kidney Injury after Cardiac Surgery ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28758975 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28758975 #FOAvip English Wikipedia <ref>{{Cite pmid|28758975 }}</ref> Elevated Soluble Urokinase Plasminogen Activator Receptor and Proenkephalin Serum Levels Predict the Development of Acute Kidney Injury after Cardiac Surgery #MMPMID28758975 Mossanen JC ; Pracht J ; Jansen TU ; Buendgens L ; Stoppe C ; Goetzenich A ; Struck J ; Autschbach R ; Marx G ; Tacke F Int J Mol Sci 2017[Jul]; 18 (8 ): ä PMID28758975 show ga Acute kidney injury (AKI) develops in up to 40% of patients after cardiac surgery. The soluble urokinase plasminogen activator receptor (suPAR) has been identified as a biomarker for incident chronic kidney disease (CKD). Proenkephalin (proENK) also has been shown to be a biomarker for renal dysfunction. We hypothesized that pre-surgery suPAR and proENK levels might predict AKI in patients undergoing cardiac surgery. Consecutive patients (n = 107) undergoing elective cardiac surgery were studied prospectively. Clinical data, laboratory parameters, suPAR and proENK serum levels were assessed before operation, after operation and days one and four post-operatively. A total of 21 (19.6%) patients developed AKI within the first four days after elective surgery. Serum levels of suPAR and proENK, but not of creatinine, were significantly higher before surgery in these patients compared to those patients without AKI. This difference remained significant for suPAR, if patients with or without AKI were matched for risk factors (hypertension, diabetes, CKD). If cardiac surgery patients with pre-existing CKD (n = 10) were excluded, only pre-operative suPAR but not proENK serum levels remained significantly elevated in patients with subsequent AKI. Thus, our findings indicate that suPAR may be a predictive biomarker for AKI in the context of cardiac surgery, even in patients without underlying CKD. |Acute Kidney Injury/*blood/etiology [MESH] |Aged [MESH] |Cardiac Surgical Procedures/*adverse effects [MESH] |Enkephalins/*blood [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Postoperative Complications/*blood [MESH] |Predictive Value of Tests [MESH] |Protein Precursors/*blood [MESH]Elevated Soluble Urokinase Plasminogen Activator Receptor and Proenkep(epmc).pdf DeepDyve Pubget Overpricing