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10.3390/ijms18081614 http://scihub22266oqcxt.onion/10.3390/ijms18081614 C5578006!5578006 !28757565     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28757565 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (8 ): ä Nephropedia Template TP {{tp|p=28757565 |t=2017. The Pharmaceutical Device Prisma(®) Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing |pdf=|usr=}}{{28757565 }} gab.com Text The Pharmaceutical Device Prisma(®) Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28757565 #FOAvip Glycosaminoglycans are polysaccharides of the extracellular matrix supporting skin wound closure. Mesoglycan is a mixture of glycosaminoglycans such as chondroitin-, dermatan-, heparan-sulfate and heparin and is the main component of Prisma(®) Skin, a pharmaceutical device developed by Mediolanum Farmaceutici S.p.a. Here, we show the in vitro effects of this device in the new vessels formation by endothelial cells, since angiogenesis represents a key moment in wound healing. We found a strong increase of migration and invasion rates of these cells treated with mesoglycan and Prisma(®) Skin which mediate the activation of the pathway triggered by CD44 receptor. Furthermore, endothelial cells form longer capillary-like structures with a great number of branches, in the presence of the same treatments. Thus, the device, thanks to the mesoglycan, leads the cells to the Endothelial-to-Mesenchymal Transition, suggesting the switch to a fibroblast-like phenotype, as shown by immunofluorescence assays. Finally, we found that mesoglycan and Prisma(®) Skin inhibit inflammatory reactions such as nitric oxide secretion and NF-?B nuclear translocation in endothelial cells and Tumor Necrosis Factor-? production by macrophages. In conclusion, based on our data, we suggest that Prisma(®) Skin may be able to accelerate angiogenesis in skin wound healing, and regulate inflammation avoiding chronic, thus pathological, responses. Twit Text FOAVip The Pharmaceutical Device Prisma(®) Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28757565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28757565 #FOAvip English Wikipedia <ref>{{Cite pmid|28757565 }}</ref> The Pharmaceutical Device Prisma(®) Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing #MMPMID28757565 Belvedere R ; Bizzarro V ; Parente L ; Petrella F ; Petrella A Int J Mol Sci 2017[Jul]; 18 (8 ): ä PMID28757565 show ga Glycosaminoglycans are polysaccharides of the extracellular matrix supporting skin wound closure. Mesoglycan is a mixture of glycosaminoglycans such as chondroitin-, dermatan-, heparan-sulfate and heparin and is the main component of Prisma(®) Skin, a pharmaceutical device developed by Mediolanum Farmaceutici S.p.a. Here, we show the in vitro effects of this device in the new vessels formation by endothelial cells, since angiogenesis represents a key moment in wound healing. We found a strong increase of migration and invasion rates of these cells treated with mesoglycan and Prisma(®) Skin which mediate the activation of the pathway triggered by CD44 receptor. Furthermore, endothelial cells form longer capillary-like structures with a great number of branches, in the presence of the same treatments. Thus, the device, thanks to the mesoglycan, leads the cells to the Endothelial-to-Mesenchymal Transition, suggesting the switch to a fibroblast-like phenotype, as shown by immunofluorescence assays. Finally, we found that mesoglycan and Prisma(®) Skin inhibit inflammatory reactions such as nitric oxide secretion and NF-?B nuclear translocation in endothelial cells and Tumor Necrosis Factor-? production by macrophages. In conclusion, based on our data, we suggest that Prisma(®) Skin may be able to accelerate angiogenesis in skin wound healing, and regulate inflammation avoiding chronic, thus pathological, responses. |Cell Movement [MESH] |Cell Survival/drug effects [MESH] |Endothelial Cells/cytology/drug effects [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Glycosaminoglycans/*pharmacology [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Hyaluronan Receptors/metabolism [MESH] |In Vitro Techniques [MESH] |Neovascularization, Physiologic/*drug effects [MESH] |Pharmaceutical Preparations [MESH] |Skin/*blood supply [MESH]The Pharmaceutical Device Prisma(®) Skin Promotes in Vitro Angiogenesi(epmc).pdf DeepDyve Pubget Overpricing