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10.1136/bmjopen-2016-013482 http://scihub22266oqcxt.onion/10.1136/bmjopen-2016-013482 C5577897!5577897 !28619765     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28619765 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMJ+Open 2017 ; 7 (6 ): e013482 Nephropedia Template TP {{tp|p=28619765 |t=2017. Early termination of cardiovascular trials as a consequence of poor accrual: analysis of ClinicalTrials gov 2006-2015 |pdf=|usr=}}{{28619765 }} gab.com Text Early termination of cardiovascular trials as a consequence of poor accrual: analysis of ClinicalTrials gov 2006-2015 JO: BMJ Open http://www.kidney.de/pget.php?&tw=1&pmid=28619765 #FOAvip OBJECTIVES: To present a snapshot of experimental cardiovascular research with a focus on geographical and temporal patterns of early termination due to poor accrual. SETTING: The Aggregate Analysis of ClinicalTrials.gov (AACT) database, reflecting ClinicalTrials.gov as of 27 March 2016. DESIGN: The AACT database was searched for all cardiovascular clinical trials that started from January 2006 up to December 2015. RESULTS: Thirteen thousand and seven hundred twenty-nine cardiovascular trials were identified. Of these, 8900 (65%) were classified as closed studies. Globally, 11% of closed trials were terminated. This proportion varied from 9.6% to 14% for trials recruiting from Europe and Americas, respectively, with a slightly decreasing trend (p=0.02) over the study period. The most common reason for trials failing to complete was poor accrual (41%). Intercontinental trials exhibited lower figures of poor accrual as the reason for their early stopping, as compared with trials recruiting in a single continent (28% vs 44%, p=0.002). CONCLUSIONS: Poor accrual significantly challenges the successful completion of cardiovascular clinical trials. Findings are suggestive of a positive effect of globalisation of cardiovascular clinical research on the achievement of enrolment goals within a reasonable time frame. Twit Text FOAVip Early termination of cardiovascular trials as a consequence of poor accrual: analysis of ClinicalTrials gov 2006-2015 ????BMJ Open http://www.kidney.de/pget.php?&tw=1&pmid=28619765 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28619765 #FOAvip English Wikipedia <ref>{{Cite pmid|28619765 }}</ref> Early termination of cardiovascular trials as a consequence of poor accrual: analysis of ClinicalTrials gov 2006-2015 #MMPMID28619765 Baldi I ; Lanera C ; Berchialla P ; Gregori D BMJ Open 2017[Jun]; 7 (6 ): e013482 PMID28619765 show ga OBJECTIVES: To present a snapshot of experimental cardiovascular research with a focus on geographical and temporal patterns of early termination due to poor accrual. SETTING: The Aggregate Analysis of ClinicalTrials.gov (AACT) database, reflecting ClinicalTrials.gov as of 27 March 2016. DESIGN: The AACT database was searched for all cardiovascular clinical trials that started from January 2006 up to December 2015. RESULTS: Thirteen thousand and seven hundred twenty-nine cardiovascular trials were identified. Of these, 8900 (65%) were classified as closed studies. Globally, 11% of closed trials were terminated. This proportion varied from 9.6% to 14% for trials recruiting from Europe and Americas, respectively, with a slightly decreasing trend (p=0.02) over the study period. The most common reason for trials failing to complete was poor accrual (41%). Intercontinental trials exhibited lower figures of poor accrual as the reason for their early stopping, as compared with trials recruiting in a single continent (28% vs 44%, p=0.002). CONCLUSIONS: Poor accrual significantly challenges the successful completion of cardiovascular clinical trials. Findings are suggestive of a positive effect of globalisation of cardiovascular clinical research on the achievement of enrolment goals within a reasonable time frame. |*Biomedical Research [MESH] |*Cardiovascular Diseases [MESH] |*Clinical Trials as Topic [MESH] |*Global Health [MESH] |Databases, Factual [MESH] |Early Termination of Clinical Trials/*statistics & numerical data [MESH] |Humans [MESH] |International Cooperation [MESH] |Research Design [MESH]Early termination of cardiovascular trials as a consequence of poor ac(epmc).pdf DeepDyve Pubget Overpricing