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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Work+Expo+Health
2017 ; 61
(2
): 164-182
Nephropedia Template TP
gab.com Text
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English Wikipedia
Urinary Bisphenol A (BPA) Concentrations among Workers in Industries that
Manufacture and Use BPA in the USA
#MMPMID28395354
Hines CJ
; Jackson MV
; Deddens JA
; Clark JC
; Ye X
; Christianson AL
; Meadows JW
; Calafat AM
Ann Work Expo Health
2017[Mar]; 61
(2
): 164-182
PMID28395354
show ga
BACKGROUND: Bisphenol A (BPA) toxicity and exposure risk to humans has been the
subject of considerable scientific debate; however, published occupational
exposure data for BPA are limited. METHODS: In 2013-2014, 77 workers at six US
companies making BPA, BPA-based resins, or BPA-filled wax provided seven urine
samples over two consecutive work days (151 worker-days, 525 samples).
Participant information included industry, job, tasks, personal protective
equipment used, hygiene behaviors, and canned food/beverage consumption. Total
(free plus conjugated) BPA, quantified in urine by mass spectrometry, was
detected in all samples. RESULTS: The geometric mean (GM) creatinine-adjusted
total BPA (total BPACR) concentration was 88.0 µg g-1 (range 0.78-18900 µg g-1),
~70 times higher than in US adults in 2013-2014 (1.27 µg g-1). GM total BPACR
increased during Day 1 (26.6-127 µg g-1), decreased by pre-shift Day 2 (84.4 µg
g-1) then increased during Day 2 to 178 µg g-1. By industry, baseline and
post-baseline total BPACR was highest in BPA-filled wax manufacturing/reclaim (GM
= 111 µg g-1) and lowest in phenolic resin manufacturing (GM = 6.56 µg g-1). By
job, total BPACR was highest at baseline in maintenance workers (GM = 157 µg g-1)
and post-baseline in those working with molten BPA-filled wax (GM = 441 µg g-1).
Workers in the job of flaking a BPA-based resin had the lowest concentrations at
baseline (GM = 4.81 µg g-1) and post-baseline (GM = 23.2 µg g-1). In multiple
regression models, at baseline, industry significantly predicted increased total
BPACR (P = 0.0248); post-baseline, handling BPA containers (P = 0.0035), taking
?3 process/bulk samples with BPA (P = 0.0002) and wearing a Tyvek® coverall (P =
0.0042) significantly predicted increased total BPACR (after adjusting for total
BPACR at baseline, time point, and body mass index). CONCLUSION: Several
work-related factors, including industry, job, and certain tasks performed, were
associated with increased urinary total BPACR concentrations in this group of
manufacturing workers. The potential for BPA-related health effects among these
workers is unknown.