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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Curr+Glaucoma+Pract
2017 ; 11
(2
): 52-57
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Assessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical
Coherence Tomography in Myopia
#MMPMID28924339
Singh D
; K Mishra S
; Agarwal E
; Sharma R
; Bhartiya S
; Dada T
J Curr Glaucoma Pract
2017[May]; 11
(2
): 52-57
PMID28924339
show ga
INTRODUCTION: To evaluate the relationship between retinal nerve fiber layer
(RNFL) thickness measured by Cirrus high-definition (HD) optical coherence
tomography (OCT) and the axial length and refractive error of the eye. MATERIALS
AND METHODS: A total of 100 eyes of 100 healthy subjects (age 20-34 years with
M/F ratio of 57/43), comprising 50 eyes with emmetropia [spherical equivalent
(SE) 0 D], 25 eyes with moderate myopia (SE between -4 D and -8 D), and 25 eyes
with high myopia (SE between -8 D and -12 D) were analyzed in this
cross-sectional study. Average and mean clock hour RNFL thicknesses were measured
by cirrus HD-OCT and compared between the three groups. Associations between RNFL
measurements and axial length and SE were evaluated by linear regression
analysis. RESULTS: The average RNFL measurements were significantly lower in high
myopia (78.68 +/- 5.67) and moderate myopia (83.76 +/- 3.44) group compared with
emmetropia group (91.26 +/- 2.99), also in the superior and inferior mean clock
hours. Significant correlations were evident between RNFL measurements and the SE
and axial length. The average RNFL thickness decreased with increasing axial
length (r = -0.8115) and negative refractive power (r = 0.8397). Myopia also
affected the RNFL thickness distribution. As the axial length increased and the
SE decreased, the thickness of the superior, inferior, and nasal peripapillary
RNFL decreased. CONCLUSION: The axial length/refractive error of the eye affected
the average RNFL thickness and the RNFL thickness distribution. Analysis of RNFL
thickness in the evaluation of glaucoma should always be interpreted with
reference to the refractive status. When interpreting the RNFL thickness of
highly myopic patients by OCT, careful attention must be given to the inherently
thinner RNFL to avoid a false diagnosis of glaucoma. HOW TO CITE THIS ARTICLE:
Singh D, Mishra SK, Agarwal E, Sharma R, Bhartiya S, Dada T. Assessment of
Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence
Tomography in Myopia. J Curr Glaucoma Pract 2017;11(2):52-57.