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10.1002/art.40060

http://scihub22266oqcxt.onion/10.1002/art.40060
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C5577002!5577002!28382778
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suck abstract from ncbi


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pmid28382778      Arthritis+Rheumatol 2017 ; 69 (5): 911-23
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  • 2016 American College of Rheumatology (ACR) - European League Against Rheumatism (EULAR) Criteria for Minimal, Moderate and Major Clinical Response for Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative #MMPMID28382778
  • Rider LG; Aggarwal R; Pistorio A; Bayat N; Erman B; Feldman BM; Huber AM; Cimaz R; Cuttica RJ; de Oliveira SK; Lindsley CB; Pilkington CA; Punaro M; Ravelli A; Reed AM; Rouster-Stevens K; van Royen A; Dressler F; Magalhaes CS; Constantin T; Davidson JE; Magnusson B; Russo R; Villa L; Rinaldi M; Rockette H; Lachenbruch PA; Miller FW; Vencovsky J; Ruperto N
  • Arthritis Rheumatol 2017[May]; 69 (5): 911-23 PMID28382778show ga
  • Objective: Develop response criteria for juvenile dermatomyositis (JDM). Methods: We analyzed the performance of 312 definitions that used core set measures (CSM) from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Pediatric Rheumatology International Trials Organization (PRINTO) and were derived from natural history data and a conjoint-analysis survey. They were further validated in the PRINTO trial of prednisone alone compared to prednisone with methotrexate or cyclosporine and the Rituximab in Myositis trial. Experts considered 14 top-performing candidate criteria based on their performance characteristics and clinical face validity using nominal group technique at a consensus conference. Results: Consensus was reached for a conjoint analysis?based continuous model with a Total Improvement Score of 0-100, using absolute percent change in CSM with thresholds for minimal (?30 points), moderate (?45), and major improvement (?70). The same criteria were chosen for adult dermatomyositis/polymyositis with differing thresholds for improvement. The sensitivity and specificity were 89% and 91-98% for minimal, 92-94% and 94-99% for moderate, and 91-98% and 85-85% for major improvement, respectively, in JDM patient cohorts using the IMACS and PRINTO CSM. These criteria were validated in the PRINTO trial for differentiating between treatment arms for minimal and moderate improvement (P=0.009?0.057) and in the Rituximab trial for significantly differentiating the physician rating of improvement (P<0.006). Conclusion: The response criteria for JDM was a conjoint analysis?based model using a continuous improvement score based on absolute percent change in CSM, with thresholds for minimal, moderate, and major improvement.
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