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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Chem+Soc+Rev 2017 ; 46 (14): 4245-80 Nephropedia Template TP
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Materials and Microfluidics: Enabling the Efficient Isolation and Analysis of Circulating Tumour Cells #MMPMID28632258
Jackson JM; Witek MA; Kamande JW; Soper SA
Chem Soc Rev 2017[Jul]; 46 (14): 4245-80 PMID28632258show ga
We present a critical review of microfluidic technologies and material effects on the analyses of circulating tumour cells (CTCs) selected from the peripheral blood of cancer patients. CTCs are a minimally invasive source of clinical information that can be used to prognose patient outcome, monitor minimal residual disease, assess tumour resistance to therapeutic agents, and potentially screen individuals for the early diagnosis of cancer. The performance of CTC isolation technologies depends on microfluidic architectures, the underyling principles of isolation, and the choice of materials. In this review, we present a critical review of the fundamental principles used in these technologies and discuss their performance. We also give context to how CTC isolation technologies enable downstream analysis of selected CTCs in terms of detecting genetic mutations and gene expression that could be used to gain information that may affect patient outcome.