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Optimal design of longitudinal data analysis using generalized estimating equation models #MMPMID27878852
Liu J; Colditz GA
Biom J 2017[Mar]; 59 (2): 315-30 PMID27878852show ga
Longitudinal studies are often applied in biomedical research and clinical trials to evaluate the treatment effect. The association pattern within the subject must be considered in both sample size calculation and the analysis. One of the most important approaches to analyze such a study is the generalized estimating equation (GEE) proposed by Liang and Zeger, in which ?working correlation structure? is introduced and the association pattern within the subject depends on a vector of association parameters denoted by ?. The explicit sample size formulas for two-group comparison in linear and logistic regression models are obtained based on the GEE method by Liu and Liang. For cluster randomized trials (CRTs), researchers proposed the optimal sample sizes at both the cluster and individual level as a function of sampling costs and the intracluster correlation coefficient (ICC). In these approaches, the optimal sample sizes depend strongly on the ICC. However, the ICC is usually unknown for cluster randomized and multicenter trials. To overcome this shortcoming, Van Breukelen et al consider a range of possible ICC values identified from literature reviews and present Maximin designs (MMDs) based on relative efficiency (RE) and efficiency under budget and cost constraints. In this paper, the optimal sample size and number of repeated measurements using GEE models with an exchangeable working correlation matrix is proposed under the considerations of fixed budget, where ?optimal? refers to maximum power for a given sampling budget. The equations of sample size and number of repeated measurements for a known parameter value ? are derived and a straightforward algorithm for unknown ? is developed. Applications in practice are discussed. We also discuss the existence of the optimal design when an AR(1) working correlation matrix is assumed. Our proposed method can be extended under the scenarios when the true and working correlation matrix are different.
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Biom+J 2017 ; 59 (2): 315-30
