Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-017-10341-x http://scihub22266oqcxt.onion/10.1038/s41598-017-10341-x C5574984!5574984 !28852218     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28852218 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 9706 Nephropedia Template TP {{tp|p=28852218 |t=2017. A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling |pdf=|usr=}}{{28852218 }} gab.com Text A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28852218 #FOAvip BPIFB4 is associated with exceptional longevity: four single-nucleotide polymorphisms distinguish the wild-type form from a longevity-associated variant conferring positive effects on blood pressure. The effect of a rare variant (RV; allele frequency, 4%) on blood pressure is unknown. Here, we show that overexpression of RV-BPIFB4 in ex-vivo mouse vessels impairs phosphorylation of endothelial nitric oxide synthase (eNOS), blunting acetylcholine-evoked vasorelaxation; in vivo, virally mediated overexpression of RV-BPIFB4 increases blood pressure, an action absent in eNOS-deficient mice. In humans, we found RV carriers to have increased diastolic blood pressure, a finding that was more marked in subjects on anti-hypertensive medication; moreover, recombinant RV-BPIFB4 protein impaired eNOS function in ex-vivo human vessels. Thus, RV-BPIFB4 acts directly on blood pressure homeostasis and may represent a novel biomarker of vascular dysfunction and hypertension. Twit Text FOAVip A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28852218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28852218 #FOAvip English Wikipedia <ref>{{Cite pmid|28852218 }}</ref> A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling #MMPMID28852218 Vecchione C ; Villa F ; Carrizzo A ; Spinelli CC ; Damato A ; Ambrosio M ; Ferrario A ; Madonna M ; Uccellatore A ; Lupini S ; Maciag A ; Ryskalin L ; Milanesi L ; Frati G ; Sciarretta S ; Bellazzi R ; Genovese S ; Ceriello A ; Auricchio A ; Malovini A ; Puca AA Sci Rep 2017[Aug]; 7 (1 ): 9706 PMID28852218 show ga BPIFB4 is associated with exceptional longevity: four single-nucleotide polymorphisms distinguish the wild-type form from a longevity-associated variant conferring positive effects on blood pressure. The effect of a rare variant (RV; allele frequency, 4%) on blood pressure is unknown. Here, we show that overexpression of RV-BPIFB4 in ex-vivo mouse vessels impairs phosphorylation of endothelial nitric oxide synthase (eNOS), blunting acetylcholine-evoked vasorelaxation; in vivo, virally mediated overexpression of RV-BPIFB4 increases blood pressure, an action absent in eNOS-deficient mice. In humans, we found RV carriers to have increased diastolic blood pressure, a finding that was more marked in subjects on anti-hypertensive medication; moreover, recombinant RV-BPIFB4 protein impaired eNOS function in ex-vivo human vessels. Thus, RV-BPIFB4 acts directly on blood pressure homeostasis and may represent a novel biomarker of vascular dysfunction and hypertension. |*Genetic Predisposition to Disease [MESH] |*Genetic Variation [MESH] |*Signal Transduction [MESH] |Aged [MESH] |Alleles [MESH] |Animals [MESH] |Biomarkers [MESH] |Blood Pressure/*genetics [MESH] |Blood Vessels/drug effects [MESH] |Female [MESH] |Gene Frequency [MESH] |Genetic Association Studies [MESH] |Haplotypes [MESH] |Humans [MESH] |Hypertension/*genetics/*metabolism/physiopathology [MESH] |Intercellular Signaling Peptides and Proteins [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Nitric Oxide/*metabolism [MESH] |Phosphoproteins/*genetics/pharmacology [MESH] |Polymorphism, Single Nucleotide [MESH]A rare genetic variant of BPIFB4 predisposes to high blood pressure vi(epmc).pdf DeepDyve Pubget Overpricing