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10.1038/s41598-017-09671-7 http://scihub22266oqcxt.onion/10.1038/s41598-017-09671-7 C5574921!5574921 !28851954     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28851954 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis |pdf=|usr=}}{{28851954 }} gab.com Text Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28851954 #FOAvip Pachydermoperiostosis (PDP) is a rare inherited multisystem disease characterized with digital clubbing, pachydermia and periostosis. Variants in either HPGD or SLCO2A1 that interrupt the prostaglandin E2 (PGE(2)) pathway have been shown to be involved in PDP. Here, in addition to six confirmed variants in HPGD or SLCO2A1, we identified four novel SLCO2A1 variants in eight PDP patients from seven Chinese Han families. In addition, gastric mucosa hyperplasia was observed in all affected individuals and interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF?) and receptor activator of nuclear factor kappa ligand (RANKL) expression were elevated in hypertrophic gastric mucosa. Two of eight patients who had severe arthralgia were treated with celecoxib. After three months, their arthralgia was partly relieved and IL-6, TNF? and RANKL expression were decreased in accordance with their relieved hypertrophic gastric mucosa. Our study broadens the variation spectrum of SLCO2A1 and suggests that the gastric mucosa hyperplasia might be a common characteristic of PDP. Moreover, celecoxib would be a considerable choice for PDP patients. We also revealed that IL-6, TNF? and RANKL may play important roles in the molecular mechanisms of gastric mucosa hyperplasia in PDP for the first time. Twit Text FOAVip Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28851954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28851954 #FOAvip English Wikipedia <ref>{{Cite pmid|28851954 }}</ref> Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis #MMPMID28851954 Huang H ; Wang Y ; Cao Y ; Wu B ; Li Y ; Fan L ; Tan Z ; Jiang Y ; Tang J ; Hu J ; Shi X Sci Rep 2017[Aug]; 7 (1 ): 9686 PMID28851954 show ga Pachydermoperiostosis (PDP) is a rare inherited multisystem disease characterized with digital clubbing, pachydermia and periostosis. Variants in either HPGD or SLCO2A1 that interrupt the prostaglandin E2 (PGE(2)) pathway have been shown to be involved in PDP. Here, in addition to six confirmed variants in HPGD or SLCO2A1, we identified four novel SLCO2A1 variants in eight PDP patients from seven Chinese Han families. In addition, gastric mucosa hyperplasia was observed in all affected individuals and interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF?) and receptor activator of nuclear factor kappa ligand (RANKL) expression were elevated in hypertrophic gastric mucosa. Two of eight patients who had severe arthralgia were treated with celecoxib. After three months, their arthralgia was partly relieved and IL-6, TNF? and RANKL expression were decreased in accordance with their relieved hypertrophic gastric mucosa. Our study broadens the variation spectrum of SLCO2A1 and suggests that the gastric mucosa hyperplasia might be a common characteristic of PDP. Moreover, celecoxib would be a considerable choice for PDP patients. We also revealed that IL-6, TNF? and RANKL may play important roles in the molecular mechanisms of gastric mucosa hyperplasia in PDP for the first time. |Biomarkers [MESH] |Biopsy [MESH] |Celecoxib/therapeutic use [MESH] |DNA Mutational Analysis [MESH] |Gastric Mucosa/*metabolism/*pathology [MESH] |Humans [MESH] |Hypertrophy [MESH] |Immunohistochemistry [MESH] |Interleukin-6/genetics/*metabolism [MESH] |Intramolecular Oxidoreductases/genetics/metabolism [MESH] |Male [MESH] |Mutation [MESH] |Organic Anion Transporters/genetics/metabolism [MESH] |Osteoarthropathy, Primary Hypertrophic/drug therapy/genetics/*metabolism/*pathology [MESH] |Pedigree [MESH] |Phenotype [MESH] |RANK Ligand/genetics/*metabolism [MESH]Interleukin-6, tumor necrosis factor-alpha and receptor activator of n(epmc).pdf DeepDyve Pubget Overpricing