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10.3389/fimmu.2017.01017

http://scihub22266oqcxt.onion/10.3389/fimmu.2017.01017
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C5574916!5574916!28890719
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suck abstract from ncbi


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pmid28890719      Front+Immunol 2017 ; 8 (ä): ä
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  • Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo #MMPMID28890719
  • Cecil JD; O?Brien-Simpson NM; Lenzo JC; Holden JA; Singleton W; Perez-Gonzalez A; Mansell A; Reynolds EC
  • Front Immunol 2017[]; 8 (ä): ä PMID28890719show ga
  • Outer membrane vesicles (OMVs) are proteoliposomes blebbed from the surface of Gram-negative bacteria. Chronic periodontitis is associated with an increase in subgingival plaque of Gram-negative bacteria, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. In this study, we investigated the immune-modulatory effects of P. gingivalis, T. denticola, and T. forsythia OMVs on monocytes and differentiated macrophages. All of the bacterial OMVs were phagocytosed by monocytes, M(naïve) and M(IFN?) macrophages in a dose-dependent manner. They also induced NF-?B activation and increased TNF?, IL-8, and IL-1? cytokine secretion. P. gingivalis OMVs were also found to induce anti-inflammatory IL-10 secretion. Although unprimed monocytes and macrophages were resistant to OMV-induced cell death, lipopolysaccharide or OMV priming resulted in a significantly reduced cell viability. P. gingivalis, T. denticola, and T. forsythia OMVs all activated inflammasome complexes, as monitored by IL-1? secretion and ASC speck formation. ASC was critical for OMV-induced inflammasome formation, while AIM2?/? and Caspase-1?/? cells had significantly reduced inflammasome formation and NLRP3?/? cells exhibited a slight reduction. OMVs were also found to provide both priming and activation of the inflammasome complex. High-resolution microscopy and flow cytometry showed that P. gingivalis OMVs primed and activated macrophage inflammasomes in vivo with 80% of macrophages exhibiting inflammasome complex formation. In conclusion, periodontal pathogen OMVs were found to have significant immunomodulatory effects upon monocytes and macrophages and should therefore influence pro-inflammatory host responses associated with disease.
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