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10.1177/2041731417725464

http://scihub22266oqcxt.onion/10.1177/2041731417725464
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C5574483!5574483!28890779
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suck abstract from ncbi

pmid28890779      J+Tissue+Eng 2017 ; 8 (ä): ä
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  • Elements of the niche for adult stem cell expansion #MMPMID28890779
  • Redondo PA; Pavlou M; Loizidou M; Cheema U
  • J Tissue Eng 2017[Jan]; 8 (ä): ä PMID28890779show ga
  • Adult stem cells are crucial for tissue homeostasis. These cells reside within exclusive locations in tissues, termed niches, which protect adult stem cell fidelity and regulate their many functions through biophysical-, biochemical- and cellular-mediated mechanisms. There is a growing understanding of how these mechanisms and their components contribute towards maintaining stem cell quiescence, self-renewal, expansion and differentiation patterns. In vitro expansion of adult stem cells is a powerful tool for understanding stem cell biology, and for tissue engineering and regenerative medicine applications. However, it is technically challenging, since adult stem cell removal from their native microenvironment has negative repercussions on their sustainability. In this review, we overview specific elements of the biomimetic niche and how recreating such elements can help in vitro propagation of adult stem cells.
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