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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Tissue+Eng
2017 ; 8
(ä): 2041731417726327
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English Wikipedia
Recellularization of decellularized heart valves: Progress toward the
tissue-engineered heart valve
#MMPMID28890780
VeDepo MC
; Detamore MS
; Hopkins RA
; Converse GL
J Tissue Eng
2017[Jan]; 8
(ä): 2041731417726327
PMID28890780
show ga
The tissue-engineered heart valve portends a new era in the field of valve
replacement. Decellularized heart valves are of great interest as a scaffold for
the tissue-engineered heart valve due to their naturally bioactive composition,
clinical relevance as a stand-alone implant, and partial recellularization in
vivo. However, a significant challenge remains in realizing the tissue-engineered
heart valve: assuring consistent recellularization of the entire valve leaflets
by phenotypically appropriate cells. Many creative strategies have pursued
complete biological valve recellularization; however, identifying the optimal
recellularization method, including in situ or in vitro recellularization and
chemical and/or mechanical conditioning, has proven difficult. Furthermore, while
many studies have focused on individual parameters for increasing valve
interstitial recellularization, a general understanding of the interacting
dynamics is likely necessary to achieve success. Therefore, the purpose of this
review is to explore and compare the various processing strategies used for the
decellularization and subsequent recellularization of tissue-engineered heart
valves.