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10.3389/fcimb.2017.00379 http://scihub22266oqcxt.onion/10.3389/fcimb.2017.00379 C5573719!5573719 !28884090     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28884090 &cmd=llinks): Failed to open stream: HTTP request failed! 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Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats |pdf=|usr=}}{{28884090 }} gab.com Text Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats JO: Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28884090 #FOAvip Osteomyelitis is commonly caused by Staphylococcus aureus. Both erythromycin and curcumin can suppress S. aureus growth, but their roles in osteomyelitis are barely studied. We aim to explore the activities of erythromycin and curcumin against chronical osteomyelitis induced by methicillin-resistant S. aureus (MRSA). Chronicle implant-induced osteomyelitis was established by MRSA infection in male Wistar rats. Four weeks after bacterial inoculation, rats received no treatment, erythromycin monotherapy, curcumin monotherapy, or erythromycin plus curcumin twice daily for 2 weeks. Bacterial levels, bone infection status, inflammatory signals and side effects were evaluated. Rats tolerated all treatments well, with no death or side effects such as, diarrhea and weight loss. Two days after treatment completion, erythromycin monotherapy did not suppress bacterial growth and had no effect in bone infection, although it reduced serum pro-inflammatory cytokines tumor necrosis factor (TNF)-? and interleukin (IL)-6. Curcumin monotherapy slightly suppressed bacterial growth, alleviated bone infection and reduced TNF-? and IL-6. Erythromycin and curcumin combined treatment markedly suppressed bacterial growth, substantially alleviated bone infection and reduced TNF-? and IL-6. Combination of erythromycin and curcumin lead a much stronger efficiency against MRSA induced osteomyelitis in rats than monotherapy. Our study suggests that erythromycin and curcumin could be a new combination for treating MRSA induced osteomyelitis. Twit Text FOAVip Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats ????Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28884090 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28884090 #FOAvip English Wikipedia <ref>{{Cite pmid|28884090 }}</ref> Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats #MMPMID28884090 Zhou Z ; Pan C ; Lu Y ; Gao Y ; Liu W ; Yin P ; Yu X Front Cell Infect Microbiol 2017[]; 7 (ä): 379 PMID28884090 show ga Osteomyelitis is commonly caused by Staphylococcus aureus. Both erythromycin and curcumin can suppress S. aureus growth, but their roles in osteomyelitis are barely studied. We aim to explore the activities of erythromycin and curcumin against chronical osteomyelitis induced by methicillin-resistant S. aureus (MRSA). Chronicle implant-induced osteomyelitis was established by MRSA infection in male Wistar rats. Four weeks after bacterial inoculation, rats received no treatment, erythromycin monotherapy, curcumin monotherapy, or erythromycin plus curcumin twice daily for 2 weeks. Bacterial levels, bone infection status, inflammatory signals and side effects were evaluated. Rats tolerated all treatments well, with no death or side effects such as, diarrhea and weight loss. Two days after treatment completion, erythromycin monotherapy did not suppress bacterial growth and had no effect in bone infection, although it reduced serum pro-inflammatory cytokines tumor necrosis factor (TNF)-? and interleukin (IL)-6. Curcumin monotherapy slightly suppressed bacterial growth, alleviated bone infection and reduced TNF-? and IL-6. Erythromycin and curcumin combined treatment markedly suppressed bacterial growth, substantially alleviated bone infection and reduced TNF-? and IL-6. Combination of erythromycin and curcumin lead a much stronger efficiency against MRSA induced osteomyelitis in rats than monotherapy. Our study suggests that erythromycin and curcumin could be a new combination for treating MRSA induced osteomyelitis. |Animals [MESH] |Anti-Bacterial Agents/*therapeutic use [MESH] |Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use [MESH] |Curcumin/*therapeutic use [MESH] |Disease Models, Animal [MESH] |Drug Synergism [MESH] |Drug Therapy, Combination [MESH] |Erythromycin/*therapeutic use [MESH] |Interleukin-6/blood [MESH] |Male [MESH] |Methicillin-Resistant Staphylococcus aureus/*drug effects/isolation & purification [MESH] |Osteomyelitis/*drug therapy/microbiology [MESH] |Rats [MESH] |Rats, Wistar [MESH] |Staphylococcal Infections/*drug therapy/microbiology [MESH]Combination of Erythromycin and Curcumin Alleviates Staphylococcus aur(epmc).pdf DeepDyve Pubget Overpricing