Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-017-09797-8 http://scihub22266oqcxt.onion/10.1038/s41598-017-09797-8 C5573375!5573375 !28842610     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28842610 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28842610 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 9409 Nephropedia Template TP {{tp|p=28842610 |t=2017. Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae |pdf=|usr=}}{{28842610 }} gab.com Text Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28842610 #FOAvip Zika virus (ZIKV) causes significant public health concerns because of its association with congenital malformations, neurological disorders in adults, and, more recently, death. Considering the necessity to mitigate ZIKV-associated diseases, antiviral interventions are an urgent necessity. Sofosbuvir, a drug in clinical use against hepatitis C virus (HCV), is among the FDA-approved substances endowed with anti-ZIKV activity. In this work, we further investigated the in vivo activity of sofosbuvir against ZIKV. Neonatal Swiss mice were infected with ZIKV (2?×?10(7) PFU) and treated with sofosbuvir at 20?mg/kg/day, a concentration compatible with pre-clinical development of this drug. We found that sofosbuvir reduced acute levels of ZIKV from 60 to 90% in different anatomical compartments, such as the blood plasma, spleen, kidney, and brain. Early treatment with sofosbuvir doubled the percentage and time of survival of ZIKV-infected animals. Sofosbuvir also prevented the acute neuromotor impairment triggered by ZIKV. In the long-term behavioural analysis of ZIKV-associated sequelae, sofosbuvir prevented loss of hippocampal- and amygdala-dependent memory. Our results indicate that sofosbuvir inhibits ZIKV replication in vivo, which is consistent with the prospective necessity of antiviral drugs to treat ZIKV-infected individuals. Twit Text FOAVip Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28842610 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28842610 #FOAvip English Wikipedia <ref>{{Cite pmid|28842610 }}</ref> Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae #MMPMID28842610 Ferreira AC ; Zaverucha-do-Valle C ; Reis PA ; Barbosa-Lima G ; Vieira YR ; Mattos M ; Silva PP ; Sacramento C ; de Castro Faria Neto HC ; Campanati L ; Tanuri A ; Brüning K ; Bozza FA ; Bozza PT ; Souza TML Sci Rep 2017[Aug]; 7 (1 ): 9409 PMID28842610 show ga Zika virus (ZIKV) causes significant public health concerns because of its association with congenital malformations, neurological disorders in adults, and, more recently, death. Considering the necessity to mitigate ZIKV-associated diseases, antiviral interventions are an urgent necessity. Sofosbuvir, a drug in clinical use against hepatitis C virus (HCV), is among the FDA-approved substances endowed with anti-ZIKV activity. In this work, we further investigated the in vivo activity of sofosbuvir against ZIKV. Neonatal Swiss mice were infected with ZIKV (2?×?10(7) PFU) and treated with sofosbuvir at 20?mg/kg/day, a concentration compatible with pre-clinical development of this drug. We found that sofosbuvir reduced acute levels of ZIKV from 60 to 90% in different anatomical compartments, such as the blood plasma, spleen, kidney, and brain. Early treatment with sofosbuvir doubled the percentage and time of survival of ZIKV-infected animals. Sofosbuvir also prevented the acute neuromotor impairment triggered by ZIKV. In the long-term behavioural analysis of ZIKV-associated sequelae, sofosbuvir prevented loss of hippocampal- and amygdala-dependent memory. Our results indicate that sofosbuvir inhibits ZIKV replication in vivo, which is consistent with the prospective necessity of antiviral drugs to treat ZIKV-infected individuals. |Animals [MESH] |Animals, Newborn [MESH] |Antiviral Agents/administration & dosage/*pharmacology [MESH] |Chlorocebus aethiops [MESH] |Memory [MESH] |Mice [MESH] |RNA, Viral [MESH] |Reflex, Righting [MESH] |Sofosbuvir/administration & dosage/*pharmacology [MESH] |Vero Cells [MESH] |Virus Replication/drug effects [MESH] |Zika Virus Infection/*drug therapy/mortality [MESH]Sofosbuvir protects Zika virus-infected mice from mortality, preventin(epmc).pdf DeepDyve Pubget Overpricing