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10.1038/s41598-017-09639-7 http://scihub22266oqcxt.onion/10.1038/s41598-017-09639-7 C5573373!5573373 !28842601     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28842601 &cmd=llinks): Failed to open stream: HTTP request failed! 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A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFN? |pdf=|usr=}}{{28842601 }} gab.com Text A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFN JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28842601 #FOAvip Macrophage polarization plays an important role in tissue damage and repair. In this study, we show that Substance-P (SP) can directly induce M2 polarization of inflammatory macrophages. SP induced the differentiation of GM-CSF-differentiated pro-inflammatory macrophages into alternatively activated phagocytic M2 like macrophages (M2(SP)) through direct activation of the PI3K/Akt/mTOR/S6kinase pathway and induction of Arginase-1, CD163, and CD206, all of which were nullified by pretreatment with the neurokinin-1 receptor (NK-1R) antagonist RP67580 and specific signaling pathway inhibitors. M2(SP) were distinct from IL-4/IL-13-induced M2a and IL-10-induced M2c subtypes; they did not show STAT activation and exhibited high phagocytic and endothelial adhesive activity. Furthermore, SP had a dominant effect on M2 polarization over Interferon gamma (IFN?), a potent M1-skewing cytokine, and effectively induced the M2 phenotype in monocytes and the human THP-1 cell line. Finally, adoptively transferred M2(SP) migrated to a spinal cord injury (SCI) lesion site and improved functional recovery. Collectively, our findings show that SP, a neuropeptide, plays a role as a novel cytokine by inducing tissue-repairing M2(SP) macrophages and thus may be developed for pharmacological intervention in diseases involving chronic inflammation and acute injury. Twit Text FOAVip A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFN ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28842601 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28842601 #FOAvip English Wikipedia <ref>{{Cite pmid|28842601 }}</ref> A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFN? #MMPMID28842601 Lim JE ; Chung E ; Son Y Sci Rep 2017[Aug]; 7 (1 ): 9417 PMID28842601 show ga Macrophage polarization plays an important role in tissue damage and repair. In this study, we show that Substance-P (SP) can directly induce M2 polarization of inflammatory macrophages. SP induced the differentiation of GM-CSF-differentiated pro-inflammatory macrophages into alternatively activated phagocytic M2 like macrophages (M2(SP)) through direct activation of the PI3K/Akt/mTOR/S6kinase pathway and induction of Arginase-1, CD163, and CD206, all of which were nullified by pretreatment with the neurokinin-1 receptor (NK-1R) antagonist RP67580 and specific signaling pathway inhibitors. M2(SP) were distinct from IL-4/IL-13-induced M2a and IL-10-induced M2c subtypes; they did not show STAT activation and exhibited high phagocytic and endothelial adhesive activity. Furthermore, SP had a dominant effect on M2 polarization over Interferon gamma (IFN?), a potent M1-skewing cytokine, and effectively induced the M2 phenotype in monocytes and the human THP-1 cell line. Finally, adoptively transferred M2(SP) migrated to a spinal cord injury (SCI) lesion site and improved functional recovery. Collectively, our findings show that SP, a neuropeptide, plays a role as a novel cytokine by inducing tissue-repairing M2(SP) macrophages and thus may be developed for pharmacological intervention in diseases involving chronic inflammation and acute injury. |Animals [MESH] |Cell Differentiation/drug effects [MESH] |Cytokines/metabolism [MESH] |Humans [MESH] |Interferon-gamma/pharmacology [MESH] |Macrophage Activation/*drug effects [MESH] |Macrophages/*drug effects/physiology [MESH] |Male [MESH] |Neurotransmitter Agents/pharmacology [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Rats, Sprague-Dawley [MESH] |Signal Transduction/*drug effects [MESH] |Substance P/*pharmacology [MESH] |THP-1 Cells [MESH]A neuropeptide, Substance-P, directly induces tissue-repairing M2 like(epmc).pdf DeepDyve Pubget Overpricing