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2017 ; 12
(8
): e0183826
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Immunosuppressant prescription pattern and trend in kidney transplantation: A
multicenter study in Korea
#MMPMID28846737
Chang JY
; Yu J
; Chung BH
; Yang J
; Kim SJ
; Kim CD
; Lee SH
; Lee JS
; Kim JK
; Jung CW
; Oh CK
; Yang CW
PLoS One
2017[]; 12
(8
): e0183826
PMID28846737
show ga
BACKGROUND: The actual prescription pattern of immunosuppressive agents in kidney
transplantation is unclear. METHODS: We investigated the pattern and trend of
immunosuppressive treatment for kidney transplant patients in South Korea. A
total of 636 patients at nine transplant centers were enrolled and followed for
one year. We reviewed medical records and evaluated induction therapy, as well as
the changing pattern and cause of maintenance therapy. RESULTS: Most patients (n
= 621, 97.6%) received induction therapy often comprising basiliximab (n = 542,
85.2%). The triple therapy including calcineurin inhibitor, mycophenolic acid,
and steroids was the major initial maintenance immunosuppression (n = 518,
81.4%), but its proportion decreased by 14% (81.4% to 67.5%) after 1 year. Almost
40% of patients changed immunosuppressive regimen during the 1-year follow-up,
most often at an early period (60.2% within the first 4 months). The primary
reason for the change was gastrointestinal discomfort (n = 113, 29.8%), followed
by infection (112, 29.6%). The most common changing pattern was mycophenolic acid
withdrawal (n = 155, 39.1%). CONCLUSION: The initial immunosuppressive regimen is
prone to change within the first year of kidney transplantation. Further studies
are needed to evaluate the benefits and risks in patients who changed
immunosuppressants.