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10.2217/rme-2016-0141

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C5572980!5572980!28524773
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suck abstract from ncbi


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pmid28524773      Regen+Med 2017 ; 12 (3): 249-61
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  • The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft #MMPMID28524773
  • Onwuka E; Best C; Sawyer A; Yi T; Heuer E; Sams M; Wiet M; Zheng H; Kyriakides T; Breuer C
  • Regen Med 2017[Apr]; 12 (3): 249-61 PMID28524773show ga
  • Aim:: Inflammatory myeloid lineage cells mediate neotissue formation in tissue-engineered vascular grafts, but the molecular mechanism is not completely understood. We examined the role of vasculogenic PDGF-B in tissue-engineered vascular graft neotissue development. Materials & methods:: Myeloid cell-specific PDGF-B knockout mice (PDGF-KO) were generated using bone marrow transplantation, and scaffolds were implanted as inferior vena cava interposition grafts in either PDGF-KO or wild-type mice. Results:: After 2 weeks, grafts from PDGF-KO mice had more remaining scaffold polymer and less intimal neotissue development. Increased macrophage apoptosis, decreased smooth muscle cell proliferation and decreased collagen content was also observed. Conclusion:: Myeloid cell-derived PDGF contributes to vascular neotissue formation by regulating macrophage apoptosis, smooth muscle cell proliferation and extracellular matrix deposition.
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