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10.1016/S2213-8587(17)30135-3 http://scihub22266oqcxt.onion/10.1016/S2213-8587(17)30135-3 C5572673!5572673!28576687     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lancet+Diabetes+Endocrinol 2017 ; 5 (9): 689-99 Nephropedia Template TP {{tp|p=28576687|t=2017. Outcome of adrenalectomy for unilateral primary aldosteronism: International consensus and remission rates |pdf=|usr=}}{{28576687}} gab.com Text Outcome of adrenalectomy for unilateral primary aldosteronism: International consensus and remission rates JO: Lancet Diabetes Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=28576687 #FOAvip Background: Although unilateral primary aldosteronism is the most common surgically correctable cause of hypertension there are no standard criteria to classify surgical outcomes. Methods: The Primary Aldosteronism Surgical Outcome study reached consensus by an international panel of 31 experts, including 6 endocrine surgeons, using the Delphi method. On the basis of standardised criteria, remission (complete, partial, absent) rates for clinical and biochemical outcomes were determined in retrospective cohorts (n=30-99) of consecutive patients unilaterally adrenalectomized based on adrenal venous sampling from 12 tertiary centres in 9 countries over 4 continents. Findings: Consensus was reached for 6 criteria of clinical and biochemical outcome and 2 recommendations for follow-up. Complete clinical success was achieved in 37% of patients, with a wide variance (17-62%), and partial clinical success in an additional 47% (35-66%); complete biochemical success was seen in 94% (83-100%). Female patients had a higher likelihood of complete clinical success (OR=2.25; 95% CI, 1.40-3.62) and clinical benefit (complete + partial clinical success) (OR=2.89; 95% CI, 1.49-5.59). Younger patients had a higher likelihood of complete clinical success (OR=0.95 per extra year; 95% CI, 0.93-0.98) and clinical benefit (OR=0.95 per extra year; 95% CI, 0.92-0.98). Higher levels of pre-operative medication were associated with lower levels of complete clinical success. Interpretation: Standardised outcome criteria are relevant for evaluating the quality of surgical treatment in individual patients and will allow the comparison of outcome data in clinical and scientific studies. The baseline clinical characteristics of a cohort contribute to the wide variation in clinical outcome rates. A majority of patients derive clinical benefit from adrenalectomy with younger patients and female patients likely to particularly benefit from a favourable surgical outcome. Screening for primary aldosteronism should nonetheless be performed in every individual fulfilling the Guideline criteria, since biochemical cure is by itself clinically important and older women and men may also derive post-operative clinical benefit. Twit Text FOAVip Outcome of adrenalectomy for unilateral primary aldosteronism: International consensus and remission rates ????Lancet Diabetes Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=28576687 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28576687 #FOAvip English Wikipedia <ref>{{Cite pmid|28576687}}</ref> Outcome of adrenalectomy for unilateral primary aldosteronism: International consensus and remission rates #MMPMID28576687 Williams TA; Lenders JW; Mulatero P; Burrello J; Rottenkolber M; Adolf C; Satoh F; Amar L; Quinkler M; Deinum J; Beuschlein F; Kitamoto KK; Pham U; Morimoto R; Umakoshi H; Prejbisz A; Kocjan T; Naruse M; Stowasser M; Nishikawa T; Young WF; Gomez-Sanchez CE; Funder JW; Reincke M Lancet Diabetes Endocrinol 2017[Sep]; 5 (9): 689-99 PMID28576687show ga Background: Although unilateral primary aldosteronism is the most common surgically correctable cause of hypertension there are no standard criteria to classify surgical outcomes. Methods: The Primary Aldosteronism Surgical Outcome study reached consensus by an international panel of 31 experts, including 6 endocrine surgeons, using the Delphi method. On the basis of standardised criteria, remission (complete, partial, absent) rates for clinical and biochemical outcomes were determined in retrospective cohorts (n=30-99) of consecutive patients unilaterally adrenalectomized based on adrenal venous sampling from 12 tertiary centres in 9 countries over 4 continents. Findings: Consensus was reached for 6 criteria of clinical and biochemical outcome and 2 recommendations for follow-up. Complete clinical success was achieved in 37% of patients, with a wide variance (17-62%), and partial clinical success in an additional 47% (35-66%); complete biochemical success was seen in 94% (83-100%). Female patients had a higher likelihood of complete clinical success (OR=2.25; 95% CI, 1.40-3.62) and clinical benefit (complete + partial clinical success) (OR=2.89; 95% CI, 1.49-5.59). Younger patients had a higher likelihood of complete clinical success (OR=0.95 per extra year; 95% CI, 0.93-0.98) and clinical benefit (OR=0.95 per extra year; 95% CI, 0.92-0.98). Higher levels of pre-operative medication were associated with lower levels of complete clinical success. Interpretation: Standardised outcome criteria are relevant for evaluating the quality of surgical treatment in individual patients and will allow the comparison of outcome data in clinical and scientific studies. The baseline clinical characteristics of a cohort contribute to the wide variation in clinical outcome rates. A majority of patients derive clinical benefit from adrenalectomy with younger patients and female patients likely to particularly benefit from a favourable surgical outcome. Screening for primary aldosteronism should nonetheless be performed in every individual fulfilling the Guideline criteria, since biochemical cure is by itself clinically important and older women and men may also derive post-operative clinical benefit. äOutcome of adrenalectomy for unilateral primary aldosteronism: Interna(epmc).pdf DeepDyve Pubget Overpricing