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10.1039/c6lc01398h http://scihub22266oqcxt.onion/10.1039/c6lc01398h C5572650!5572650!28233001     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28233001&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lab+Chip 2017 ; 17 (6): 1104-15 Nephropedia Template TP {{tp|p=28233001|t=2017. Subcellular Probes for Neurochemical Recording from Multiple Brain Sites |pdf=|usr=}}{{28233001}} gab.com Text Subcellular Probes for Neurochemical Recording from Multiple Brain Sites JO: Lab Chip http://www.kidney.de/pget.php?&tw=1&pmid=28233001 #FOAvip Dysregulation of neurochemicals, in particular, dopamine, is epitomized in numerous debilitating disorders that impair normal movement and mood aspects of our everyday behavior. Neurochemical transmission is a neuron-specific process, and further exhibits region-specific signaling in the brain. Tools are needed to monitor the heterogeneous spatiotemporal dynamics of dopamine neurotransmission without compromising the physiological processes of the neuronal environment. We developed neurochemical probes that are ten times smaller than any existing dopamine sensor, based on the size of the entire implanted shaft and its sensing tip. The microfabricated probe occupies a spatial footprint (9 ?m) coordinate with the average size of individual neuronal cells (~10 ?m). These cellular-scale probes were shown to reduce inflammatory response of the implanted brain tissue environment. The probes are further configured in the form of a microarray to permit electrochemical sampling of dopamine and other neurotransmitters at unprecedented spatial densities and distributions. Dopamine recording was performed concurrently from up to 16 sites in the striatum of rats, revealing a remarkable spatiotemporal contrast in dopamine transmission as well as site-specific pharmacological modulation. Collectively, the reported platform endeavors to enable high density mapping of the chemical messengers fundamentally involved in neuronal communication through the use of minimally invasive probes that help preserve neuronal viability of the implant environment. Twit Text FOAVip Subcellular Probes for Neurochemical Recording from Multiple Brain Sites ????Lab Chip http://www.kidney.de/pget.php?&tw=1&pmid=28233001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28233001 #FOAvip English Wikipedia <ref>{{Cite pmid|28233001}}</ref> Subcellular Probes for Neurochemical Recording from Multiple Brain Sites #MMPMID28233001 Schwerdt HN; Kim M; Amemori S; Homma D; Yoshida T; Shimazu H; Yerramreddy H; Karasan E; Langer R; Graybiel AM; Cima MJ Lab Chip 2017[Mar]; 17 (6): 1104-15 PMID28233001show ga Dysregulation of neurochemicals, in particular, dopamine, is epitomized in numerous debilitating disorders that impair normal movement and mood aspects of our everyday behavior. Neurochemical transmission is a neuron-specific process, and further exhibits region-specific signaling in the brain. Tools are needed to monitor the heterogeneous spatiotemporal dynamics of dopamine neurotransmission without compromising the physiological processes of the neuronal environment. We developed neurochemical probes that are ten times smaller than any existing dopamine sensor, based on the size of the entire implanted shaft and its sensing tip. The microfabricated probe occupies a spatial footprint (9 ?m) coordinate with the average size of individual neuronal cells (~10 ?m). These cellular-scale probes were shown to reduce inflammatory response of the implanted brain tissue environment. The probes are further configured in the form of a microarray to permit electrochemical sampling of dopamine and other neurotransmitters at unprecedented spatial densities and distributions. Dopamine recording was performed concurrently from up to 16 sites in the striatum of rats, revealing a remarkable spatiotemporal contrast in dopamine transmission as well as site-specific pharmacological modulation. Collectively, the reported platform endeavors to enable high density mapping of the chemical messengers fundamentally involved in neuronal communication through the use of minimally invasive probes that help preserve neuronal viability of the implant environment. äSubcellular Probes for Neurochemical Recording from Multiple Brain Sit(epmc).pdf DeepDyve Pubget Overpricing