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10.1186/s40792-017-0370-7

http://scihub22266oqcxt.onion/10.1186/s40792-017-0370-7
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C5572476!5572476!28842844
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suck abstract from ncbi


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pmid28842844      Surg+Case+Rep 2017 ; 3 (ä): ä
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  • Intestinal perforation after nivolumab immunotherapy for a malignant melanoma: a case report #MMPMID28842844
  • Yasuda K; Tanaka T; Ishihara S; Otani K; Nishikawa T; Kiyomatsu T; Kawai K; Hata K; Nozawa H; Masui Y; Shintani Y; Watanabe T
  • Surg Case Rep 2017[Dec]; 3 (ä): ä PMID28842844show ga
  • Background: Nivolumab is a monoclonal antibody against programmed death 1 and has become a standard treatment of advanced melanoma because of its durable response and survival benefits. In this report, we present a case of severe intestinal perforation after nivolumab immunotherapy for malignant melanoma. Case presentation: A 73-year-old man with stage IV malignant melanoma underwent nivolumab therapy. The patient presented to our hospital because of a progressing abdominal pain. Radiological evaluation revealed evidence of free intraperitoneal air. Therefore, we diagnosed the patient as having an intestinal perforation, which was successfully resolved after surgical treatment. Conclusion: Although intestinal perforation after nivolumab immunotherapy is rare, it can be severe and requires early diagnosis and emergency surgery to ensure a favorable prognosis.
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