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2017 ; 8
(ä): 1593
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Myxobacteria Are Able to Prey Broadly upon Clinically-Relevant Pathogens,
Exhibiting a Prey Range Which Cannot Be Explained by Phylogeny
#MMPMID28878752
Livingstone PG
; Morphew RM
; Whitworth DE
Front Microbiol
2017[]; 8
(ä): 1593
PMID28878752
show ga
Myxobacteria are natural predators of microorganisms and the subjects of
concerted efforts to identify novel antimicrobial compounds. Myxobacterial
predatory activity seems to require more than just the possession of specific
antimicrobial metabolites. Thus a holistic approach to studying predation
promises novel insights into antimicrobial action. Here, we report the isolation
of 113 myxobacteria from samples of soil taken from a range of habitats in mid
Wales. Predatory activity of each isolate was quantified against a panel of
clinically important prey organisms, including Klebsiella pneumoniae, Proteus
mirabilis, Candida albicans, Enterococcus faecalis, and three species of
Staphylococcus. Myxobacterial isolates exhibited a wide range of predation
activity profiles against the panel of prey. Efficient predation of all prey by
isolates within the collection was observed, with K. pneumoniae and C. albicans
proving particularly susceptible to myxobacterial predation. Notably efficient
predators tended to be proficient at predating multiple prey organisms,
suggesting they possess gene(s) encoding a broad range killing activity. However,
predatory activity was not congruent with phylogeny, suggesting prey range is
subject to relatively rapid specialization, potentially involving lateral gene
transfer. The broad but patchy prey ranges observed for natural myxobacterial
isolates also implies multiple (potentially overlapping) genetic determinants are
responsible for dictating predatory activity.