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2017 ; 96
(34
): e7698
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A Bayesian network meta-analysis of whole brain radiotherapy and stereotactic
radiotherapy for brain metastasis
#MMPMID28834873
Yuan X
; Liu WJ
; Li B
; Shen ZT
; Shen JS
; Zhu XX
Medicine (Baltimore)
2017[Aug]; 96
(34
): e7698
PMID28834873
show ga
This study was conducted to compare the effects of whole brain radiotherapy
(WBRT) and stereotactic radiotherapy (SRS) in treatment of brain metastasis.A
systematical retrieval in PubMed and Embase databases was performed for relative
literatures on the effects of WBRT and SRS in treatment of brain metastasis. A
Bayesian network meta-analysis was performed by using the ADDIS software. The
effect sizes included odds ratio (OR) and 95% confidence interval (CI). A random
effects model was used for the pooled analysis for all the outcome measures,
including 1-year distant control rate, 1-year local control rate, 1-year survival
rate, and complication. The consistency was tested by using node-splitting
analysis and inconsistency standard deviation. The convergence was estimated
according to the Brooks-Gelman-Rubin method.A total of 12 literatures were
included in this meta-analysis. WBRT?+?SRS showed higher 1-year distant control
rate than SRS. WBRT?+?SRS was better for the 1-year local control rate than WBRT.
SRS and WBRT?+?SRS had higher 1-year survival rate than the WBRT. In addition,
there was no difference in complication among the three
therapies.Comprehensively, WBRT?+?SRS might be the choice of treatment for brain
metastasis.