Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s12265-017-9759-8 http://scihub22266oqcxt.onion/10.1007/s12265-017-9759-8 C5571647!5571647!28681133     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28681133.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cardiovasc+Transl+Res 2017 ; 10 (3): 322-36 Nephropedia Template TP {{tp|p=28681133|t=2017. Innovative Clinical Trial Designs for Precision Medicine in Heart Failure with Preserved Ejection Fraction |pdf=|usr=}}{{28681133}} gab.com Text Innovative Clinical Trial Designs for Precision Medicine in Heart Failure with Preserved Ejection Fraction JO: J Cardiovasc Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=28681133 #FOAvip A major challenge in the care of patients with heart failure and preserved ejection fraction (HFpEF) is the lack of proven therapies due to disappointing results from randomized controlled trials (RCTs). The heterogeneity of the HFpEF syndrome and the use of conventional RCT designs are possible reasons underlying the failure of these trials. There are several factors? including the widespread adoption of electronic health records, decreasing costs of obtaining high-dimensional data, and the availability of a wide variety of potential therapeutics?that have evolved to enable more innovative clinical trial designs in HFpEF. Here we review the current landscape of HFpEF RCTs and present several innovative RCT designs that could be implemented in HFpEF, including enrichment trials, adaptive trials, umbrella trials, basket trials, and machine learning-based trials (including examples for each). Our hope is that the description of the aforementioned innovative trial designs will stimulate new approaches to clinical trials in HFpEF. Twit Text FOAVip Innovative Clinical Trial Designs for Precision Medicine in Heart Failure with Preserved Ejection Fraction ????J Cardiovasc Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=28681133 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28681133 #FOAvip English Wikipedia <ref>{{Cite pmid|28681133}}</ref> Innovative Clinical Trial Designs for Precision Medicine in Heart Failure with Preserved Ejection Fraction #MMPMID28681133 Shah SJ J Cardiovasc Transl Res 2017[Jun]; 10 (3): 322-36 PMID28681133show ga A major challenge in the care of patients with heart failure and preserved ejection fraction (HFpEF) is the lack of proven therapies due to disappointing results from randomized controlled trials (RCTs). The heterogeneity of the HFpEF syndrome and the use of conventional RCT designs are possible reasons underlying the failure of these trials. There are several factors? including the widespread adoption of electronic health records, decreasing costs of obtaining high-dimensional data, and the availability of a wide variety of potential therapeutics?that have evolved to enable more innovative clinical trial designs in HFpEF. Here we review the current landscape of HFpEF RCTs and present several innovative RCT designs that could be implemented in HFpEF, including enrichment trials, adaptive trials, umbrella trials, basket trials, and machine learning-based trials (including examples for each). Our hope is that the description of the aforementioned innovative trial designs will stimulate new approaches to clinical trials in HFpEF. äInnovative Clinical Trial Designs for Precision Medicine in Heart Fail(epmc).pdf DeepDyve Pubget Overpricing