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10.1111/jcmm.13117 http://scihub22266oqcxt.onion/10.1111/jcmm.13117 C5571552!5571552 !28266128     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28266128 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2017 ; 21 (9 ): 1967-1978 Nephropedia Template TP {{tp|p=28266128 |t=2017. Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice |pdf=|usr=}}{{28266128 }} gab.com Text Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28266128 #FOAvip Accumulating evidence demonstrates that hypoxia-inducible factor (HIF-?) hydroxylase system has a critical role in vascular remodelling. Using an endothelial-specific prolyl hydroxylase domain protein-2 (PHD2) knockout (PHD2(EC) KO) mouse model, this study investigates the regulatory role of endothelial HIF-? hydroxylase system in the development of renal fibrosis. Knockout of PHD2 in EC up-regulated the expression of HIF-1? and HIF-2?, resulting in a significant decline of renal function as evidenced by elevated levels of serum creatinine. Deletion of PHD2 increased the expression of Notch3 and transforming growth factor (TGF-?1) in EC, thus further causing glomerular arteriolar remodelling with an increased pericyte and pericyte coverage. This was accompanied by a significant elevation of renal resistive index (RI). Moreover, knockout of PHD2 in EC up-regulated the expression of fibroblast-specific protein-1 (FSP-1) and increased interstitial fibrosis in the kidney. These alterations were strongly associated with up-regulation of Notch3 and TGF-?1. We concluded that the expression of PHD2 in endothelial cells plays a critical role in renal fibrosis and vascular remodelling in adult mice. Furthermore, these changes were strongly associated with up-regulation of Notch3/TGF-?1 signalling and excessive pericyte coverage. Twit Text FOAVip Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28266128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28266128 #FOAvip English Wikipedia <ref>{{Cite pmid|28266128 }}</ref> Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice #MMPMID28266128 Wang S ; Zeng H ; Chen ST ; Zhou L ; Xie XJ ; He X ; Tao YK ; Tuo QH ; Deng C ; Liao DF ; Chen JX J Cell Mol Med 2017[Sep]; 21 (9 ): 1967-1978 PMID28266128 show ga Accumulating evidence demonstrates that hypoxia-inducible factor (HIF-?) hydroxylase system has a critical role in vascular remodelling. Using an endothelial-specific prolyl hydroxylase domain protein-2 (PHD2) knockout (PHD2(EC) KO) mouse model, this study investigates the regulatory role of endothelial HIF-? hydroxylase system in the development of renal fibrosis. Knockout of PHD2 in EC up-regulated the expression of HIF-1? and HIF-2?, resulting in a significant decline of renal function as evidenced by elevated levels of serum creatinine. Deletion of PHD2 increased the expression of Notch3 and transforming growth factor (TGF-?1) in EC, thus further causing glomerular arteriolar remodelling with an increased pericyte and pericyte coverage. This was accompanied by a significant elevation of renal resistive index (RI). Moreover, knockout of PHD2 in EC up-regulated the expression of fibroblast-specific protein-1 (FSP-1) and increased interstitial fibrosis in the kidney. These alterations were strongly associated with up-regulation of Notch3 and TGF-?1. We concluded that the expression of PHD2 in endothelial cells plays a critical role in renal fibrosis and vascular remodelling in adult mice. Furthermore, these changes were strongly associated with up-regulation of Notch3/TGF-?1 signalling and excessive pericyte coverage. |*Sequence Deletion [MESH] |*Vascular Remodeling [MESH] |Animals [MESH] |Arteries/pathology [MESH] |Arterioles/pathology [MESH] |Blood Pressure [MESH] |Fibrosis [MESH] |Gene Expression Regulation [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism [MESH] |Hypoxia-Inducible Factor-Proline Dioxygenases/*metabolism [MESH] |Kidney Glomerulus/pathology/physiopathology [MESH] |Kidney/*blood supply/*pathology/physiopathology [MESH] |Mice, Knockout [MESH] |Pericytes/metabolism/pathology [MESH]Ablation of endothelial prolyl hydroxylase domain protein-2 promotes r(epmc).pdf DeepDyve Pubget Overpricing