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10.1111/jcmm.13124 http://scihub22266oqcxt.onion/10.1111/jcmm.13124 C5571551!5571551!28276625     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28276625.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2017 ; 21 (9): 2046-54 Nephropedia Template TP {{tp|p=28276625|t=2017. NKG2D ligand RAE1? induces generation and enhances the inhibitor function of myeloid?derived suppressor cells in mice |pdf=|usr=}}{{28276625}} gab.com Text NKG2D ligand RAE1 induces generation and enhances the inhibitor function of myeloid derived suppressor cells in mice JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28276625 #FOAvip Expression of surface NKG2D ligands on tumour cells, which activates nature killer (NK) cells and CD8+ T cells, is crucial in antitumour immunity. Some types of tumours have evolved mechanisms to suppress NKG2D?mediated immune cell activation, such as tumour?derived soluble NKG2D ligands or sustained NKG2D ligands produced by tumours down?regulate the expression of NKG2D on NK cells and CD8+ T cells. Here, we report that surface NKG2D ligand RAE1? on tumour cells induces CD11b+Gr?1+ myeloid?derived suppressor cell (MDSC) via NKG2D in vitro and in vivo. MDSCs induced by RAE1? display a robust induction of IL?10 and arginase, and these MDSCs show greater suppressive activity by inhibiting antigen?non?specific CD8+ T?cell proliferation. Consistently, upon adoptive transfer, MDSCs induced by RAE1? significantly promote CT26 tumour growth in IL?10? and arginase?dependent manners. RAE1? moves cytokine balance towards Th2 but not Th1 in vivo. Furthermore, RAE1? enhances inhibitory function of CT26?derived MDSCs and promotes IL?4 rather than IFN?? production from CT26?derived MDSCs through NKG2D in vitro. Our study has demonstrated a novel mechanism for NKG2D ligand+ tumour cells escaping from immunosurveillance by facilitating the proliferation and the inhibitory function of MDSCs. Twit Text FOAVip NKG2D ligand RAE1 induces generation and enhances the inhibitor function of myeloid derived suppressor cells in mice ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28276625 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28276625 #FOAvip English Wikipedia <ref>{{Cite pmid|28276625}}</ref> NKG2D ligand RAE1? induces generation and enhances the inhibitor function of myeloid?derived suppressor cells in mice #MMPMID28276625 Qian L; Liu Y; Wang S; Gong W; Jia X; Liu L; Ye F; Ding J; Xu Y; Fu Y; Tian F J Cell Mol Med 2017[Sep]; 21 (9): 2046-54 PMID28276625show ga Expression of surface NKG2D ligands on tumour cells, which activates nature killer (NK) cells and CD8+ T cells, is crucial in antitumour immunity. Some types of tumours have evolved mechanisms to suppress NKG2D?mediated immune cell activation, such as tumour?derived soluble NKG2D ligands or sustained NKG2D ligands produced by tumours down?regulate the expression of NKG2D on NK cells and CD8+ T cells. Here, we report that surface NKG2D ligand RAE1? on tumour cells induces CD11b+Gr?1+ myeloid?derived suppressor cell (MDSC) via NKG2D in vitro and in vivo. MDSCs induced by RAE1? display a robust induction of IL?10 and arginase, and these MDSCs show greater suppressive activity by inhibiting antigen?non?specific CD8+ T?cell proliferation. Consistently, upon adoptive transfer, MDSCs induced by RAE1? significantly promote CT26 tumour growth in IL?10? and arginase?dependent manners. RAE1? moves cytokine balance towards Th2 but not Th1 in vivo. Furthermore, RAE1? enhances inhibitory function of CT26?derived MDSCs and promotes IL?4 rather than IFN?? production from CT26?derived MDSCs through NKG2D in vitro. Our study has demonstrated a novel mechanism for NKG2D ligand+ tumour cells escaping from immunosurveillance by facilitating the proliferation and the inhibitory function of MDSCs. äNKG2D ligand RAE1? induces generation and enhances the inhibitor funct(epmc).pdf DeepDyve Pubget Overpricing