Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/jcmm.13124 http://scihub22266oqcxt.onion/10.1111/jcmm.13124 C5571551!5571551 !28276625     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28276625 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2017 ; 21 (9 ): 2046-2054 Nephropedia Template TP {{tp|p=28276625 |t=2017. NKG2D ligand RAE1? induces generation and enhances the inhibitor function of myeloid-derived suppressor cells in mice |pdf=|usr=}}{{28276625 }} gab.com Text NKG2D ligand RAE1 induces generation and enhances the inhibitor function of myeloid-derived suppressor cells in mice JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28276625 #FOAvip Expression of surface NKG2D ligands on tumour cells, which activates nature killer (NK) cells and CD8(+) T cells, is crucial in antitumour immunity. Some types of tumours have evolved mechanisms to suppress NKG2D-mediated immune cell activation, such as tumour-derived soluble NKG2D ligands or sustained NKG2D ligands produced by tumours down-regulate the expression of NKG2D on NK cells and CD8(+) T cells. Here, we report that surface NKG2D ligand RAE1? on tumour cells induces CD11b(+) Gr-1(+) myeloid-derived suppressor cell (MDSC) via NKG2D in vitro and in vivo. MDSCs induced by RAE1? display a robust induction of IL-10 and arginase, and these MDSCs show greater suppressive activity by inhibiting antigen-non-specific CD8(+) T-cell proliferation. Consistently, upon adoptive transfer, MDSCs induced by RAE1? significantly promote CT26 tumour growth in IL-10- and arginase-dependent manners. RAE1? moves cytokine balance towards Th2 but not Th1 in vivo. Furthermore, RAE1? enhances inhibitory function of CT26-derived MDSCs and promotes IL-4 rather than IFN-? production from CT26-derived MDSCs through NKG2D in vitro. Our study has demonstrated a novel mechanism for NKG2D ligand(+) tumour cells escaping from immunosurveillance by facilitating the proliferation and the inhibitory function of MDSCs. Twit Text FOAVip NKG2D ligand RAE1 induces generation and enhances the inhibitor function of myeloid-derived suppressor cells in mice ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28276625 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28276625 #FOAvip English Wikipedia <ref>{{Cite pmid|28276625 }}</ref> NKG2D ligand RAE1? induces generation and enhances the inhibitor function of myeloid-derived suppressor cells in mice #MMPMID28276625 Qian L ; Liu Y ; Wang S ; Gong W ; Jia X ; Liu L ; Ye F ; Ding J ; Xu Y ; Fu Y ; Tian F J Cell Mol Med 2017[Sep]; 21 (9 ): 2046-2054 PMID28276625 show ga Expression of surface NKG2D ligands on tumour cells, which activates nature killer (NK) cells and CD8(+) T cells, is crucial in antitumour immunity. Some types of tumours have evolved mechanisms to suppress NKG2D-mediated immune cell activation, such as tumour-derived soluble NKG2D ligands or sustained NKG2D ligands produced by tumours down-regulate the expression of NKG2D on NK cells and CD8(+) T cells. Here, we report that surface NKG2D ligand RAE1? on tumour cells induces CD11b(+) Gr-1(+) myeloid-derived suppressor cell (MDSC) via NKG2D in vitro and in vivo. MDSCs induced by RAE1? display a robust induction of IL-10 and arginase, and these MDSCs show greater suppressive activity by inhibiting antigen-non-specific CD8(+) T-cell proliferation. Consistently, upon adoptive transfer, MDSCs induced by RAE1? significantly promote CT26 tumour growth in IL-10- and arginase-dependent manners. RAE1? moves cytokine balance towards Th2 but not Th1 in vivo. Furthermore, RAE1? enhances inhibitory function of CT26-derived MDSCs and promotes IL-4 rather than IFN-? production from CT26-derived MDSCs through NKG2D in vitro. Our study has demonstrated a novel mechanism for NKG2D ligand(+) tumour cells escaping from immunosurveillance by facilitating the proliferation and the inhibitory function of MDSCs. |Animals [MESH] |CD11b Antigen/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Female [MESH] |Interleukin-10/metabolism [MESH] |Interleukin-4/metabolism [MESH] |Ligands [MESH] |Mice, Inbred BALB C [MESH] |Myeloid-Derived Suppressor Cells/*metabolism [MESH] |NK Cell Lectin-Like Receptor Subfamily K/*metabolism [MESH] |Neoplasms/pathology [MESH] |Nuclear Matrix-Associated Proteins/*metabolism [MESH]NKG2D ligand RAE1? induces generation and enhances the inhibitor funct(epmc).pdf DeepDyve Pubget Overpricing