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10.1111/jcmm.13120 http://scihub22266oqcxt.onion/10.1111/jcmm.13120 C5571535!5571535!28266181     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2017 ; 21 (9): 2000-8 Nephropedia Template TP {{tp|p=28266181|t=2017. MiR?9 is involved in TGF??1?induced lung cancer cell invasion and adhesion by targeting SOX7 |pdf=|usr=}}{{28266181}} gab.com Text MiR 9 is involved in TGF 1 induced lung cancer cell invasion and adhesion by targeting SOX7 JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28266181 #FOAvip MicroRNA (miR)?9 plays different roles in different cancer types. Here, we investigated the role of miR?9 in non?small?cell lung cancer (NSCLC) cell invasion and adhesion in vitro and explored whether miR?9 was involved in transforming growth factor?beta 1 (TGF??1)?induced NSCLC cell invasion and adhesion by targeting SOX7. The expression of miR?9 and SOX7 in human NSCLC tissues and cell lines was examined by reverse transcription?quantitative polymerase chain reaction. Gain?of?function and loss?of?function experiments were performed on A549 and HCC827 cells to investigate the effect of miR?9 and SOX7 on NSCLC cell invasion and adhesion in the presence or absence of TGF??1. Transwell?Matrigel assay and cell adhesion assay were used to examine cell invasion and adhesion abilities. Luciferase reporter assay was performed to determine whether SOX7 was a direct target of miR?9. We found miR?9 was up?regulated and SOX7 was down?regulated in human NSCLC tissues and cell lines. Moreover, SOX7 expression was negatively correlated with miR?9 expression. miR?9 knockdown or SOX7 overexpression could suppress TGF??1?induced NSCLC cell invasion and adhesion. miR?9 directly targets the 3? untranslated region of SOX7, and SOX7 protein expression was down?regulated by miR?9. TGF??1 induced miR?9 expression in NSCLC cells. miR?9 up?regulation led to enhanced NSCLC cell invasion and adhesion; however, these effects could be attenuated by SOX7 overexpression. We concluded that miR?9 expression was negatively correlated with SOX7 expression in human NSCLC. miR?9 was up?regulated by TGF??1 and contributed to TGF??1?induced NSCLC cell invasion and adhesion by directly targeting SOX7. Twit Text FOAVip MiR 9 is involved in TGF 1 induced lung cancer cell invasion and adhesion by targeting SOX7 ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28266181 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28266181 #FOAvip English Wikipedia <ref>{{Cite pmid|28266181}}</ref> MiR?9 is involved in TGF??1?induced lung cancer cell invasion and adhesion by targeting SOX7 #MMPMID28266181 Han L; Wang W; Ding W; Zhang L J Cell Mol Med 2017[Sep]; 21 (9): 2000-8 PMID28266181show ga MicroRNA (miR)?9 plays different roles in different cancer types. Here, we investigated the role of miR?9 in non?small?cell lung cancer (NSCLC) cell invasion and adhesion in vitro and explored whether miR?9 was involved in transforming growth factor?beta 1 (TGF??1)?induced NSCLC cell invasion and adhesion by targeting SOX7. The expression of miR?9 and SOX7 in human NSCLC tissues and cell lines was examined by reverse transcription?quantitative polymerase chain reaction. Gain?of?function and loss?of?function experiments were performed on A549 and HCC827 cells to investigate the effect of miR?9 and SOX7 on NSCLC cell invasion and adhesion in the presence or absence of TGF??1. Transwell?Matrigel assay and cell adhesion assay were used to examine cell invasion and adhesion abilities. Luciferase reporter assay was performed to determine whether SOX7 was a direct target of miR?9. We found miR?9 was up?regulated and SOX7 was down?regulated in human NSCLC tissues and cell lines. Moreover, SOX7 expression was negatively correlated with miR?9 expression. miR?9 knockdown or SOX7 overexpression could suppress TGF??1?induced NSCLC cell invasion and adhesion. miR?9 directly targets the 3? untranslated region of SOX7, and SOX7 protein expression was down?regulated by miR?9. TGF??1 induced miR?9 expression in NSCLC cells. miR?9 up?regulation led to enhanced NSCLC cell invasion and adhesion; however, these effects could be attenuated by SOX7 overexpression. We concluded that miR?9 expression was negatively correlated with SOX7 expression in human NSCLC. miR?9 was up?regulated by TGF??1 and contributed to TGF??1?induced NSCLC cell invasion and adhesion by directly targeting SOX7. äMiR?9 is involved in TGF??1?induced lung cancer cell invasion and adhe(epmc).pdf DeepDyve Pubget Overpricing