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2017 ; 21
(9
): 1698-1710
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Endothelial microparticles act as novel diagnostic and therapeutic biomarkers of
circulatory hypoxia-related diseases: a literature review
#MMPMID28316143
Deng F
; Wang S
; Zhang L
J Cell Mol Med
2017[Sep]; 21
(9
): 1698-1710
PMID28316143
show ga
Circulatory hypoxia-related diseases (CHRDs), including acute coronary syndromes,
stroke and organ transplantation, attract increased attention due to high
morbidity and mortality. Mounting evidence shows that hypoxia-induced oxidative
stress, coagulation, inflammation and angiogenesis play extremely important roles
in the physiological and pathological processes of CHRD-related vascular
endothelial injury. Interestingly, hypoxia, even hypoxia-induced oxidative
stress, coagulation and inflammation can all induce release of endothelial
microparticles (EMPs). EMPs, shed from activated or apoptotic endothelial cells
(ECs), reflect the degree of EC damage, and elevated EMP levels are found in
several CHRDs. Furthermore, EMPs, which play an important role in cell-to-cell
communication and function, have confirmed pro-coagulant, proinflammatory,
angiogenic and other functions, affecting pathological processes. These findings
suggest that EMPs and CHRDs have a very close relationship, and EMPs may help to
identify CHRD phenotypes and stratify the severity of disease, to improve risk
stratification for developing CHRDs, to better define prophylactic strategies and
to ameliorate prognostic characterization of patients with CHRDs. This review
summarizes the known and potential roles of EMPs in the diagnosis, staging,
treatment and clinical prognosis of CHRDs.