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10.1038/s41598-017-09673-5 http://scihub22266oqcxt.onion/10.1038/s41598-017-09673-5 C5571156!5571156 !28839277     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28839277 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 9289 Nephropedia Template TP {{tp|p=28839277 |t=2017. Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-?1/Smads and PI3K/Akt pathways |pdf=|usr=}}{{28839277 }} gab.com Text Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF- 1/Smads and PI3K/Akt pathways JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28839277 #FOAvip The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a characteristic response to acute or chronic liver injury. Mice were randomized to bile duct ligation (BDL) or carbon tetrachloride (CCl(4)) cirrhosis models. Quercetin (100?mg/kg or 200?mg/kg daily) was administered by gavage for 2 or 4 weeks. Liver tissue and blood samples were collected for histological and molecular analysis. The results of our experiments showed that quercetin reduced BDL or CCl(4) liver fibrosis, inhibited extracellular matrix formation, and regulated matrix metallopeptidase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1. Quercetin attenuated liver damage by suppressing the TGF-?1/Smads signaling pathway and activating the PI3K/Akt signaling pathway to inhibit autophagy in BDL- or CCl(4)- induced liver fibrosis. Quercetin prevented hepatic fibrosis by attenuating hepatic stellate cell activation and reducing autophagy through regulating crosstalk between the TGF-?1/Smads and PI3K/Akt pathways. Twit Text FOAVip Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF- 1/Smads and PI3K/Akt pathways ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28839277 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28839277 #FOAvip English Wikipedia <ref>{{Cite pmid|28839277 }}</ref> Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-?1/Smads and PI3K/Akt pathways #MMPMID28839277 Wu L ; Zhang Q ; Mo W ; Feng J ; Li S ; Li J ; Liu T ; Xu S ; Wang W ; Lu X ; Yu Q ; Chen K ; Xia Y ; Lu J ; Xu L ; Zhou Y ; Fan X ; Guo C Sci Rep 2017[Aug]; 7 (1 ): 9289 PMID28839277 show ga The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a characteristic response to acute or chronic liver injury. Mice were randomized to bile duct ligation (BDL) or carbon tetrachloride (CCl(4)) cirrhosis models. Quercetin (100?mg/kg or 200?mg/kg daily) was administered by gavage for 2 or 4 weeks. Liver tissue and blood samples were collected for histological and molecular analysis. The results of our experiments showed that quercetin reduced BDL or CCl(4) liver fibrosis, inhibited extracellular matrix formation, and regulated matrix metallopeptidase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1. Quercetin attenuated liver damage by suppressing the TGF-?1/Smads signaling pathway and activating the PI3K/Akt signaling pathway to inhibit autophagy in BDL- or CCl(4)- induced liver fibrosis. Quercetin prevented hepatic fibrosis by attenuating hepatic stellate cell activation and reducing autophagy through regulating crosstalk between the TGF-?1/Smads and PI3K/Akt pathways. |Animals [MESH] |Autophagy/drug effects [MESH] |Biopsy [MESH] |Carbon Tetrachloride/adverse effects [MESH] |Disease Models, Animal [MESH] |Extracellular Matrix/metabolism [MESH] |Gene Expression [MESH] |Hepatic Stellate Cells/*drug effects/*metabolism [MESH] |Liver Cirrhosis/*etiology/*metabolism/pathology/prevention & control [MESH] |Liver Function Tests [MESH] |Matrix Metalloproteinase 9/genetics/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Phosphatidylinositol 3-Kinases/*metabolism [MESH] |Proto-Oncogene Proteins c-akt/*metabolism [MESH] |Quercetin/pharmacology [MESH] |Signal Transduction/*drug effects [MESH] |Smad Proteins/*metabolism [MESH] |Tissue Inhibitor of Metalloproteinase-1/genetics/metabolism [MESH]Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cel(epmc).pdf DeepDyve Pubget Overpricing