Garcia-Peterson LM; Wilking-Busch MJ; Ndiaye MA; Philippe CGA; Setaluri V; Ahmad N
Skin Pharmacol Physiol 2017[]; 30 (4): 216-24 PMID28704830show ga
The sirtuins are a family of proteins that comprise Class III of the histone deacetylases. These NAD+ dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In addition, recent research is unraveling the role of sirtuins in a variety of skin diseases, including melanoma and non-melanoma skin cancers. In this review, we provide a discussion on the potential roles and implications of different sirtuins in skin-specific cellular processes, which may have relevance to skin health and skin diseases. Based on the available literature, the sirtuins appear to be important targets in the management of a variety of skin diseases from cosmetic conditions (e.g. skin aging) to fatal conditions (e.g. melanoma).