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10.1016/j.immuni.2017.06.019 http://scihub22266oqcxt.onion/10.1016/j.immuni.2017.06.019 C5568648!5568648!28723548     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2017 ; 47 (1): 159-170.e10 Nephropedia Template TP {{tp|p=28723548|t=2017. The Fc domain of immunoglobulin is sufficient to bridge NK cells with virally infected cells |pdf=|usr=}}{{28723548}} gab.com Text The Fc domain of immunoglobulin is sufficient to bridge NK cells with virally infected cells JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28723548 #FOAvip Clearance of pathogens or tumor cells by antibodies traditionally requires both Fab and Fc domains of IgG. Here we show the Fc domain of IgG alone mediates recognition and clearance of herpes simplex virus (HSV1) infected cells. The human natural killer (NK) cell surface is naturally coated with IgG bound by its Fc domain to the Fc? receptor CD16a. NK cells utilize the Fc domain of bound IgG to recognize gE, an HSV1-encoded glycoprotein that also binds the Fc domain of IgG but at a site distinct from CD16a. The bridge formed by Fc domain between the HSV1-infected cell and the NK cell results in NK cell activation and lysis of the HSV1-infected cell in the absence of HSV1-specific antibody in vitro, and prevents fatal HSV1 infection in vivo. This mechanism also explains how bacterial IgG-binding proteins regulate NK cell function, and may be broadly applicable to Fc? receptor-bearing cells. Twit Text FOAVip The Fc domain of immunoglobulin is sufficient to bridge NK cells with virally infected cells ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28723548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28723548 #FOAvip English Wikipedia <ref>{{Cite pmid|28723548}}</ref> The Fc domain of immunoglobulin is sufficient to bridge NK cells with virally infected cells #MMPMID28723548 Dai HS(; Griffin N; Bolyard C; Mao HC; Zhang J; Cripe TP; Suenaga T; Arase H; Nakano I; Chiocca EA; Kaur B; Yu J; Caligiuri MA Immunity 2017[Jul]; 47 (1): 159-170.e10 PMID28723548show ga Clearance of pathogens or tumor cells by antibodies traditionally requires both Fab and Fc domains of IgG. Here we show the Fc domain of IgG alone mediates recognition and clearance of herpes simplex virus (HSV1) infected cells. The human natural killer (NK) cell surface is naturally coated with IgG bound by its Fc domain to the Fc? receptor CD16a. NK cells utilize the Fc domain of bound IgG to recognize gE, an HSV1-encoded glycoprotein that also binds the Fc domain of IgG but at a site distinct from CD16a. The bridge formed by Fc domain between the HSV1-infected cell and the NK cell results in NK cell activation and lysis of the HSV1-infected cell in the absence of HSV1-specific antibody in vitro, and prevents fatal HSV1 infection in vivo. This mechanism also explains how bacterial IgG-binding proteins regulate NK cell function, and may be broadly applicable to Fc? receptor-bearing cells. äThe Fc domain of immunoglobulin is sufficient to bridge NK cells with (epmc).pdf DeepDyve Pubget Overpricing