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10.1042/CS20160381 http://scihub22266oqcxt.onion/10.1042/CS20160381 C5567781!5567781!28798076     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Sci+(Lond) 2017 ; 131 (17): 2257-74 Nephropedia Template TP {{tp|p=28798076|t=2017. Perivascular Spaces, Glymphatic Dysfunction, and Small Vessel Disease |pdf=|usr=}}{{28798076}} gab.com Text Perivascular Spaces, Glymphatic Dysfunction, and Small Vessel Disease JO: Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=28798076 #FOAvip Cerebral small vessel diseases (SVD) range broadly in etiology but share a remarkably overlapping pathology. Features of SVD including enlarged perivascular spaces and formation of abluminal protein deposits cannot be completely explained by the putative pathophysiology. The recently discovered glymphatic system provides a new perspective to potentially address these gaps. This work provides a comprehensive review of the known factors that regulate glymphatic function and the disease mechanisms underlying glymphatic impairment emphasizing the role that aquaporin-4 (AQP4)-lined perivascular spaces, cerebrovascular pulsatility, and metabolite clearance play in normal CNS physiology. This review also discusses the implications that glymphatic impairment may have on SVD inception and progression with the aim of exploring novel therapeutic targets and highlighting the key questions that remain to be answered. Twit Text FOAVip Perivascular Spaces, Glymphatic Dysfunction, and Small Vessel Disease ????Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=28798076 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28798076 #FOAvip English Wikipedia <ref>{{Cite pmid|28798076}}</ref> Perivascular Spaces, Glymphatic Dysfunction, and Small Vessel Disease #MMPMID28798076 Mestre H; Kostrikov S; Mehta RI; Nedergaard M Clin Sci (Lond) 2017[Sep]; 131 (17): 2257-74 PMID28798076show ga Cerebral small vessel diseases (SVD) range broadly in etiology but share a remarkably overlapping pathology. Features of SVD including enlarged perivascular spaces and formation of abluminal protein deposits cannot be completely explained by the putative pathophysiology. The recently discovered glymphatic system provides a new perspective to potentially address these gaps. This work provides a comprehensive review of the known factors that regulate glymphatic function and the disease mechanisms underlying glymphatic impairment emphasizing the role that aquaporin-4 (AQP4)-lined perivascular spaces, cerebrovascular pulsatility, and metabolite clearance play in normal CNS physiology. This review also discusses the implications that glymphatic impairment may have on SVD inception and progression with the aim of exploring novel therapeutic targets and highlighting the key questions that remain to be answered. äPerivascular Spaces, Glymphatic Dysfunction, and Small Vessel Disease (epmc).pdf DeepDyve Pubget Overpricing