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10.1038/s41598-017-09702-3 http://scihub22266oqcxt.onion/10.1038/s41598-017-09702-3 C5567271!5567271 !28831172     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28831172 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 9030 Nephropedia Template TP {{tp|p=28831172 |t=2017. Pioglitazone Enhances Cytosolic Lipolysis, ?-oxidation and Autophagy to Ameliorate Hepatic Steatosis |pdf=|usr=}}{{28831172 }} gab.com Text Pioglitazone Enhances Cytosolic Lipolysis, -oxidation and Autophagy to Ameliorate Hepatic Steatosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28831172 #FOAvip Non-alcoholic fatty liver disease closely contributes to the development of obesity and insulin resistance. Even though pioglitazone has been reported to effectively lessen hepatic steatosis in human studies, its molecular mechanism remains unclear. This study is designed to investigate the regulation of cytosolic lipolysis, ?-oxidation and autophagy by pioglitazone in a mice model of high fat diet (HFD) and cell model incubated with palmitic acid. Our results revealed hepatic steatosis was apparently induced by HFD and it was significantly reversed by pioglitazone. The serum insulin and hepatic triglyceride content was significantly decreased by co-administered pioglitazone with HFD. Hepatic expression of cytosolic-lipolysis related proteins (ATGL, HSL), ?-oxidation (CPT-1A) and autophagy-related proteins (ATG7, LC3, LAL) was significantly enhanced by pioglitazone. Knockdown PPAR?/PPAR? in AML12 cells significantly and proportionally reduced the expressions of ATGL, CPT-1A and LC3II, which was induced by pioglitazone. Furthermore, facilitation of the autophagic flux by pioglitazone was obviously blocked by lysosomal inhibitor, leupeptin, to demonstrate accumulation of the LC3II and intracellular lipid in AML12 cells. Our results demonstrated that pioglitazone attenuating the hepatic steatosis may be mediated by enhancing cytosolic lipolysis, ?-oxidation and autophagy in a PPAR? and PPAR? dependent manner. Twit Text FOAVip Pioglitazone Enhances Cytosolic Lipolysis, -oxidation and Autophagy to Ameliorate Hepatic Steatosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28831172 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28831172 #FOAvip English Wikipedia <ref>{{Cite pmid|28831172 }}</ref> Pioglitazone Enhances Cytosolic Lipolysis, ?-oxidation and Autophagy to Ameliorate Hepatic Steatosis #MMPMID28831172 Hsiao PJ ; Chiou HC ; Jiang HJ ; Lee MY ; Hsieh TJ ; Kuo KK Sci Rep 2017[Aug]; 7 (1 ): 9030 PMID28831172 show ga Non-alcoholic fatty liver disease closely contributes to the development of obesity and insulin resistance. Even though pioglitazone has been reported to effectively lessen hepatic steatosis in human studies, its molecular mechanism remains unclear. This study is designed to investigate the regulation of cytosolic lipolysis, ?-oxidation and autophagy by pioglitazone in a mice model of high fat diet (HFD) and cell model incubated with palmitic acid. Our results revealed hepatic steatosis was apparently induced by HFD and it was significantly reversed by pioglitazone. The serum insulin and hepatic triglyceride content was significantly decreased by co-administered pioglitazone with HFD. Hepatic expression of cytosolic-lipolysis related proteins (ATGL, HSL), ?-oxidation (CPT-1A) and autophagy-related proteins (ATG7, LC3, LAL) was significantly enhanced by pioglitazone. Knockdown PPAR?/PPAR? in AML12 cells significantly and proportionally reduced the expressions of ATGL, CPT-1A and LC3II, which was induced by pioglitazone. Furthermore, facilitation of the autophagic flux by pioglitazone was obviously blocked by lysosomal inhibitor, leupeptin, to demonstrate accumulation of the LC3II and intracellular lipid in AML12 cells. Our results demonstrated that pioglitazone attenuating the hepatic steatosis may be mediated by enhancing cytosolic lipolysis, ?-oxidation and autophagy in a PPAR? and PPAR? dependent manner. |Animals [MESH] |Autophagy/*drug effects [MESH] |Cell Line [MESH] |Diet, High-Fat/adverse effects [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Insulin/blood [MESH] |Leupeptins/pharmacology [MESH] |Lipolysis/*drug effects [MESH] |Male [MESH] |Mice [MESH] |Non-alcoholic Fatty Liver Disease/chemically induced/*drug therapy/metabolism [MESH] |Oxidation-Reduction/*drug effects [MESH] |PPAR alpha/metabolism [MESH] |PPAR gamma/metabolism [MESH] |Palmitic Acid/adverse effects [MESH] |Pioglitazone/*administration & dosage/pharmacology [MESH]Pioglitazone Enhances Cytosolic Lipolysis, ?-oxidation and Autophagy t(epmc).pdf DeepDyve Pubget Overpricing